Fishburne J I, Greiss F C, Hopkinson R, Rhyne A L
Am J Obstet Gynecol. 1979 Apr 1;133(7):753-61. doi: 10.1016/0002-9378(79)90112-1.
Responses of the uterine vasculature and myometrium to uterine arterial infusions of local anesthetic agents were evaluated in chronically prepared conscious ewes between 86 and 141 days of gestation. Decreases in uterine blood flow (UBF) with increasing levels of anesthetic drugs were similar to those previously observed in nonpregnant ewes. A 25% decrease in UBF occurred at 7 micrograms of bupivacaine, 11.5 micrograms of 2-chloroprocaine, and 19.5 micrograms of lidocaine per milliliter of control UBF. Myometrial tonus did not change significantly except with bupivacaine where an increase occurred (P less than 0.001). These data indicate that local anesthetic agents may lower gravid UBF by a direct vascular effect and by stimulation of myometrial contractility. The possible clinical implications of these observations are discussed.
在妊娠86至141天的长期制备的清醒母羊中，评估子宫血管系统和子宫肌层对子宫动脉注入局部麻醉剂的反应。随着麻醉药物水平的增加，子宫血流量（UBF）的减少与之前在未怀孕母羊中观察到的相似。每毫升对照UBF中，布比卡因7微克、2-氯普鲁卡因11.5微克和利多卡因19.5微克时，UBF下降25%。除布比卡因使子宫肌层张力增加（P<0.001）外，子宫肌层张力无显著变化。这些数据表明，局部麻醉剂可能通过直接血管效应和刺激子宫肌层收缩来降低妊娠子宫的血流量。讨论了这些观察结果可能的临床意义。
