Lanz E, Schlereth H
Anaesthesist. 1979 Jan;28(1):18-24.
11 non-pregnant sheep were prepared for chronic studies with an electromagnetic flow transducer placed around one uterine artery and with catheters in both uterine veins, aorta and inferior vena cava. The 4 local anaesthetics bupivacaine, etidocaine, lignocaine and chloroprocaine were infused intravenously on consecutive days in a randomized manner. During the infusions of all 4 local anaesthetics, uterine blood flow decreased due to an increase of uterine vascular resistance. The uterine arteriovenous O2-difference increased, while the uterine O2-consumption decreased without development of an acidosis of the uterus. The same changes were observed in 8 animals, to which oestrone had been administered intravenously prior to the infusions of local anaesthetics. Local anaesthetics had the same effects in the non-pregnant and pregnant uterus. A direct vasoconstrictive mechanism on the uterine vessels as well as a depressing effect on metabolism is discussed for the local anaesthetics.
11只未怀孕的绵羊被准备用于慢性研究，在一条子宫动脉周围放置电磁流量传感器，并在两条子宫静脉、主动脉和下腔静脉中插入导管。连续数天以随机方式静脉注射布比卡因、依替卡因、利多卡因和氯普鲁卡因这4种局部麻醉药。在所有4种局部麻醉药输注期间，由于子宫血管阻力增加，子宫血流量减少。子宫动静脉氧差增加，而子宫氧消耗减少，且未出现子宫酸中毒。在8只动物中观察到了相同的变化，这些动物在输注局部麻醉药之前已静脉注射了雌酮。局部麻醉药在未怀孕子宫和怀孕子宫中的作用相同。讨论了局部麻醉药对子宫血管的直接血管收缩机制以及对代谢的抑制作用。
