细胞骨架结构参与神经生长因子介导的鸟氨酸脱羧酶诱导过程。
Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase.
作者信息
Lakshmanan J
出版信息
Biochem J. 1979 Jan 15;178(1):245-8. doi: 10.1042/bj1780245.
Abstract
Induction of ornithine decarboxylase elicited in response to nerve-growth factor in target organs is greatly decreased by preincubation of these tissues with cytoskeletal poisons such as vinblastine, diamide, cytochalasin B and colchicine. These results are interpreted as evidence for the involvement of receptor-associated cytoskeletal structures in mediating the nerve-growth-factor-specific induction of ornithine decarboxylase.
摘要
在用诸如长春花碱、二酰胺、细胞松弛素B和秋水仙碱等细胞骨架毒物对这些组织进行预孵育后，靶器官中由神经生长因子诱导产生的鸟氨酸脱羧酶会大幅减少。这些结果被解释为受体相关细胞骨架结构参与介导神经生长因子特异性诱导鸟氨酸脱羧酶的证据。
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