脑室内注射神经生长因子可诱导大鼠外周组织中的鸟氨酸脱羧酶。
Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat.
作者信息
Nagaiah K, Ikeno T, Lakshmanan J, MacDonnell P, Guroff G
出版信息
Proc Natl Acad Sci U S A. 1978 May;75(5):2512-5. doi: 10.1073/pnas.75.5.2512.
Abstract
Intraventricular administration of nerve growth factor causes an increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in liver, kidney, and adrenal as well as in brain itself. An increase in the concentration of corticosterone in the blood was also observed. Adrenalectomy, hypophysectomy, or pituitary stalk section inhibits the increase of ornithine decarboxylase activity in the peripheral tissues. Ornithine decarboxylase activity in the brain, however, responds to nerve growth factor in these animals. The data indicate that nerve growth factor causes an acitivation of the hypothalamo-hypophyseal endocrine system.
摘要
脑室内注射神经生长因子会导致肝脏、肾脏、肾上腺以及脑本身中鸟氨酸脱羧酶（L-鸟氨酸羧基裂解酶，EC 4.1.1.17）的活性增加。还观察到血液中皮质酮浓度升高。肾上腺切除术、垂体切除术或垂体柄切断术会抑制外周组织中鸟氨酸脱羧酶活性的增加。然而，这些动物脑中的鸟氨酸脱羧酶活性对神经生长因子有反应。数据表明神经生长因子会激活下丘脑-垂体内分泌系统。
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