Sheela Rani C S, Moudgal N R
Endocrinology. 1979 May;104(5):1480-3. doi: 10.1210/endo-104-5-1480.
The ability of FSH to stimulate the activity of ornithine decarboxylase (ODC) in the ovary of the immature rat and cycling hamster has been examined using specific antisera to gonadotropins. The stimulatory effect of FSH on ODC activity in the ovary of the immature rat was abolished when LH antiserum was administered along with FSH, while similar administration of FSH antiserum had no effect on LH action in stimulating ODC activity, thereby demonstrating the specificity of the LH effect. During the estrus cycle of the hamster, ODC activity in the ovary could be detected only on the evening of proestrus, the maximal activity seen at 1700 h being associated with both the Graafian follicles and the rest of the ovarian tissue. Neutralization of the proestrous FSH surge had no effect on the activity of ODC in either of these tissues, while similar administration of LH antiserum at 1300 h of proestrus completely inhibited the ODC activity in both large follicles and the rest of the ovarian tissue. Thus, the surge of LH, but not of FSH, appears to be responsible for regulating the ODC activity in the ovary of the cycling hamster.
利用促性腺激素特异性抗血清，研究了促卵泡激素（FSH）刺激未成熟大鼠和性周期仓鼠卵巢中鸟氨酸脱羧酶（ODC）活性的能力。当FSH与促黄体生成素（LH）抗血清同时给药时，FSH对未成熟大鼠卵巢中ODC活性的刺激作用消失，而类似地给予FSH抗血清对LH刺激ODC活性的作用没有影响，从而证明了LH作用的特异性。在仓鼠的发情周期中，仅在发情前期的晚上可检测到卵巢中的ODC活性，在1700 h观察到的最大活性与格拉夫卵泡和卵巢其余组织均有关。中和发情前期的FSH峰对这两种组织中ODC的活性均无影响，而在发情前期1300 h类似地给予LH抗血清则完全抑制了大卵泡和卵巢其余组织中的ODC活性。因此，LH峰而非FSH峰似乎负责调节性周期仓鼠卵巢中的ODC活性。
