Mosnaim A D, Wolf M E, Huprikar S, Singh S P, Zeller E A
Diabetes. 1979 May;28(5):455-6. doi: 10.2337/diab.28.5.455.
Insulin-dependent diabetics show a significant reduction in blood platelets' monoamine oxidase (MAO) activity when compared with age-matched and sex-matched controls. This does not appear to be the case for diabetics either on diet control or receiving oral hypoglycemic drugs. The important role of this enzyme in the regulation of the circulating levels of a number of monoamines known to have an inhibitory effect on insulin secretion may indicate the possible inclusion of the MAO/monoamine system in the pathophysiology of diabetes. The possibility of using platelets' MAO activity as a biologic marker for a subgroup of insulin-dependent diabetics is also discussed.
与年龄和性别匹配的对照组相比，胰岛素依赖型糖尿病患者血小板中的单胺氧化酶（MAO）活性显著降低。对于通过饮食控制或接受口服降糖药治疗的糖尿病患者，情况似乎并非如此。已知该酶在调节多种对胰岛素分泌有抑制作用的单胺的循环水平中起重要作用，这可能表明MAO/单胺系统可能参与了糖尿病的病理生理过程。文中还讨论了将血小板MAO活性用作胰岛素依赖型糖尿病亚组生物学标志物的可能性。
