Oakberg E F
In Vitro. 1979 Jan;15(1):41-9. doi: 10.1007/BF02627078.
Follicles were classified on the basis of the number of layers of follicle cells, the presence and degree of development of the zone pellucide, and the presence of an antrum. Formation of an antrum in follicles with less than 7 to 8 cell layers and/or presence of necrotic cells was considered indicative of degeneration. When classified in this manner, the data suggest that follicles and their contained oocytes are committed to either normal development or atresia by the time a third layer of granulosa cells is formed.
卵泡根据卵泡细胞层数、透明带的存在及发育程度以及卵泡腔的存在进行分类。卵泡细胞层数少于7至8层和/或存在坏死细胞时卵泡腔的形成被视为退化的标志。按这种方式分类时，数据表明在颗粒细胞第三层形成时，卵泡及其所含的卵母细胞就已注定要么正常发育要么闭锁。
