Södersten P, Hansen S
J Endocrinol. 1979 Mar;80(3):389-95. doi: 10.1677/joe.0.0800389.
The ability of cyclic female rats to show sexual receptivity 24 h after an injection of 2 microgram oestradiol benzoate (OB) was lost 24 h after ovariectomy. Exposure of cyclic rats to antioestrogen (nitromophene monocitrate) implants 24 h before ovariectomy and OB treatment prevented the latter from inducing sexual receptivity within 24 h of administration. Treatment of ovariectomized rats with constant release implants filled with an oil solution of 15 microgram oestradiol/ml had no behavioural effect in itself, but prepared the rats to show lordosis 24 h after administration of OB. Progesterone treatment (4 mg) induced sexual behaviour in cyclic rats on days other than that of the oestrous cycle when the rats are normally receptive. Evidence is presented that a lower level of oestradiol stimulation than that present duing pro-oestrus was needed for the induction of sexual receptivity in ovariectomized rats. It is suggested that the low basal level of oestradiol which was present throughout the oestrous cycle was necessary for the induction of sexual receptivity and that an increase in oestradial stimulation served to increase the behavioural sensitivity to progesterone.
切除卵巢24小时后，处于发情周期的雌性大鼠在注射2微克苯甲酸雌二醇（OB）后24小时表现出性接受能力的能力丧失。在切除卵巢和进行OB处理前24小时，将处于发情周期的大鼠暴露于抗雌激素（单柠檬酸硝莫酚）植入物中，可防止后者在给药后24小时内诱导性接受能力。用填充有15微克雌二醇/毫升油溶液的缓释植入物治疗切除卵巢的大鼠本身没有行为影响，但使大鼠在给予OB后24小时表现出脊柱前凸。孕酮处理（4毫克）在发情周期中大鼠通常具有接受能力的日子以外的其他日子诱导处于发情周期的大鼠出现性行为。有证据表明，在切除卵巢的大鼠中诱导性接受能力所需的雌二醇刺激水平低于发情前期的水平。有人提出，在整个发情周期中存在的低基础雌二醇水平对于诱导性接受能力是必要的，而雌二醇刺激的增加有助于提高对孕酮的行为敏感性。
