Kelly R H, Harvey V S
Int Arch Allergy Appl Immunol. 1979;59(3):273-80. doi: 10.1159/000232270.
Evidence for enhanced extravasation of thoracic duct lymph-borne immuno-blasts within joints of rats during the onset of adjuvant disease was sought by adoptive transfer of cells radiolabeled with (125I)-iodo-2-deoxyuridine. Migratory behavior of cells from normal or adjuvant disease donors, during both inductive and overt stages of the disease process, was contrasted in normal and adjuvant disease recipients. The results provided no evidence to indicate enhanced joint-seeking properties of lymph-borne immuno-blasts obtained from adjuvant disease donors, either during the period preceding overt joint involvement or during the phase of chronic inflammation. The ability of lymph-borne cells to passively transfer the disease thus appears more likely due to systemic actions of these cells, mediators produced by them, or concomitantly passaged antigen upon patterns of inflammatory cell mobilization and/or vascular endothelial cell activation.
通过对用（125I）-碘-2-脱氧尿苷进行放射性标记的细胞进行过继转移，来探寻佐剂病发作期间大鼠关节内胸导管淋巴源性免疫母细胞渗出增强的证据。在疾病过程的诱导期和明显期，将正常或佐剂病供体的细胞在正常和佐剂病受体中的迁移行为进行了对比。结果没有提供证据表明，无论是在明显的关节受累之前的时期，还是在慢性炎症阶段，从佐剂病供体获得的淋巴源性免疫母细胞具有增强的向关节趋化特性。因此，淋巴源性细胞被动转移疾病的能力似乎更可能是由于这些细胞的全身作用、它们产生的介质，或伴随传递的抗原对炎症细胞动员模式和/或血管内皮细胞激活的影响。
