Kelly R H, Harvey V S
Am J Pathol. 1978 May;91(2):345-54.
Evidence for selective extravasation of thoracic duct lymph-borne cells, derived from rats with adjuvant disease, within joints of normal or adjuvant arthritic recipients was sough by adoptive transfer of radiolabeled cells. Control studies were carried out in parallel using thoracic ducts cells from normal donors. No increased homing of lymph-borne cells to inflamed portions of the limbs was detected when cells from adjuvant arthritic donors were compared with those of normal controls. Inflammatory changes, ie, adjuvant-induced disease, in the recipient produced a significant nonspecific enhancement of extravasation; cells from normal and adjuvant arthritic donors responded equally well. One difference in migratory behavior between lymph-borne cells from adjuvant arthritic and normal animals was the increased ability of the former to localize within certain lymph nodes. A possible association between this traffic and the development of chronic inflammatory processes within joints is discussed.
通过放射性标记细胞的过继转移，寻找来自佐剂病大鼠的胸导管淋巴携带细胞在正常或佐剂性关节炎受体关节内选择性外渗的证据。同时使用来自正常供体的胸导管细胞进行对照研究。当将佐剂性关节炎供体的细胞与正常对照的细胞进行比较时，未检测到淋巴携带细胞向肢体炎症部位的归巢增加。受体中的炎症变化，即佐剂诱导的疾病，产生了显著的非特异性外渗增强；来自正常和佐剂性关节炎供体的细胞反应同样良好。佐剂性关节炎动物和正常动物的淋巴携带细胞在迁移行为上的一个差异是，前者在某些淋巴结内定位的能力增强。讨论了这种细胞迁移与关节内慢性炎症过程发展之间的可能关联。
