Jokinen M, Gahmberg C G, Andersson L C
Nature. 1979 Jun 14;279(5714):604-7. doi: 10.1038/279604a0.
During biosynthesis of glycophorin A in K562 cells a precursor is rapidly transferred through the endoplasmic reticulum membrane with the COOH-terminal remaining in the cytoplasm. This is glycosylated within the cell and appears at the cell surface after about 30 min. The biosynthetic pathway resembles that described for viral membrane glycoproteins.
在K562细胞中血型糖蛋白A的生物合成过程中,一种前体迅速穿过内质网膜,其羧基末端留在细胞质中。这种前体在细胞内被糖基化,并在大约30分钟后出现在细胞表面。其生物合成途径类似于已描述的病毒膜糖蛋白的途径。