Annegers J F, Hauser W A, Elveback L R, Kurland L T
Neurology. 1979 Mar;29(3):297-303. doi: 10.1212/wnl.29.3.297.
A cohort of 666 children who had convulsions with fever were followed to determine the risks of subsequent epilepsy. High risks were found in children with preexisting cerebral palsy or mental retardation. Other major risk factors were atypical features of the febrile convulsions (such as focal seizures) and duration of febrile seizures for 10 minuts or more. The risk of developing epilepsy by age 20 was about 6 percent for all children who had experienced febrile convulsions. However, this risk figure consisted of a combination of 2.5 percent of children without prior neurologic disorder or atypical or prolonged seizures, and 17 percent of those with such complications.
对666名曾因发热出现惊厥的儿童进行随访,以确定其后续发生癫痫的风险。研究发现,患有脑瘫或智力障碍的儿童风险较高。其他主要风险因素包括热性惊厥的非典型特征(如局灶性发作)以及热性惊厥持续10分钟或更长时间。所有曾经历过热性惊厥的儿童到20岁时患癫痫的风险约为6%。然而,这一风险数字由两部分组成,一部分是无既往神经系统疾病、无惊厥非典型特征或惊厥未延长的儿童,其风险为2.5%;另一部分是有此类并发症的儿童,其风险为17%。