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长期摄入乙醇后对固定时间间隔强化程序习得的损害。

Impairment of acquisition of a DRL schedule following prolonged ethanol consumption.

作者信息

Denoble V J, Begleiter H

出版信息

Pharmacol Biochem Behav. 1979 Mar;10(3):393-6. doi: 10.1016/0091-3057(79)90203-x.

DOI:10.1016/0091-3057(79)90203-x
PMID:572062
Abstract

Two groups of male hooded rats (N = 9) were given either ethanol or sucrose solutions as their only source of fluid for six months. Thirty days after the ethanol treatment, the rats were reduced to 85% of their free-feeding weights and allowed to obtain 45 mg of food pellets on an FR 1 schedule fof five consecutive days. Subsequently, the rats were tested on four DRL schedules (6. 12, 18, 24 sec). There was no difference between the two groups on FR 1 or DRL 6 sec schedules; however, when the DRL interval was lengthened to 12, 18, and 24 sec, the ethanol group required more sessions than the sucrose group to reach criterion performance. After increases in the DRL interval, the modal interresponse time of the ethanol group shifted more slowly than that of the sucrose group.

摘要

两组雄性带帽大鼠(N = 9)被给予乙醇或蔗糖溶液作为其六个月内唯一的液体来源。乙醇处理30天后,大鼠体重降至自由进食体重的85%,并按固定比率1的程序连续五天每天获取45毫克食丸。随后,对大鼠进行四种差分强化低速率(DRL)程序(6、12、18、24秒)测试。在固定比率1或DRL 6秒程序上,两组之间没有差异;然而,当DRL间隔延长至12、18和24秒时,乙醇组比蔗糖组需要更多的训练次数才能达到标准表现。在DRL间隔增加后,乙醇组的模式反应间隔比蔗糖组变化得更慢。

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