Rudolf G A, Tölle R
Psychiatr Clin (Basel). 1978;11(4):198-212. doi: 10.1159/000283752.
The effect of total sleep deprivation for one night on the depressive state (measured using the depression rating scale of Bojanovsky and Chloupkova) and the patients' actual state of well being (measured using the self-rating scale of von Zerssen) is investigated in a group of 40 randomly selected inpatient depressives (29 endogenous depressives, 11 neurotic depressives) over a period of 36 h. The endogenous depressives exhibited a statistically significant change. The total index of the depression scale improved by 22.6%, recorded as a 'daily mean difference'. The individual symptoms of depressive mood, lack of interest, inhibition and inappetence were significantly improved. The feature of vital disorders and its common appearance with diurnal variations correlates positively with the degree of sleep deprivation effect. The symptomatology of the neurotic depressive patients also showed a significant improvement but the relatively small group of particularly severe neurotic depressives who also exhibited vital disorders is not representative. In a group of cases, sleep deprivation caused reversion in the depressive symptomatology not only during the night of deprivation but influenced the diurnal rhythm of the depressive symptomatology on the following day, in a therapeutically favourable direction. The results are compared with those of other studies. The methodological problems are discussed and methodological improvements for further investigation are proposed.
在一组40名随机选取的住院抑郁症患者（29名内源性抑郁症患者，11名神经症性抑郁症患者）中，研究了一晚完全睡眠剥夺对抑郁状态（使用博亚诺夫斯基和克洛普科娃抑郁评定量表测量）和患者实际幸福感状态（使用冯·泽尔森自评量表测量）的影响，为期36小时。内源性抑郁症患者出现了具有统计学意义的变化。抑郁量表的总指数提高了22.6%，记录为“每日平均差异”。抑郁情绪、兴趣缺乏、抑制和食欲不振等个体症状有显著改善。生命紊乱特征及其与昼夜变化的共同出现与睡眠剥夺效应程度呈正相关。神经症性抑郁症患者的症状学也有显著改善，但一小群特别严重且也表现出生命紊乱的神经症性抑郁症患者不具有代表性。在一组病例中，睡眠剥夺不仅在剥夺当晚导致抑郁症状学逆转，而且在第二天以治疗有利的方向影响抑郁症状学的昼夜节律。将结果与其他研究结果进行了比较。讨论了方法学问题，并提出了进一步研究的方法学改进建议。
