Nalbandian R M, Henry R L, Bick R L
Semin Thromb Hemost. 1979 Winter;5(3):216-40. doi: 10.1055/s-0028-1087154.
A hypothesis for the pathogenesis of TTP is developed, centered on the views and findings of Kwaan (Fig. 8). By a series of deductions, inferences, and extensions, an attempt has been made to define considerably more restrictively than heretofore a TTP paradigm of clinical (Tables 1,2,3) and laboratory (Table 4) features. Revisions may be required in the future as increase of knowledge indicates. By similar methods rational, exigent therapeutic measures are selected (Table 5). The innovative therapeutic use of plasma transfusion, as proposed by Byrnes and Lian and their co-workers, is compatible with the paradigm in all respects. The paradigm discriminates for authentic cases of TTP among spurious if similar entities. Such sequestration will constitute a homogeneous universe of case material appropriate for study. The prospective use of the TTP paradigm defined in this papd therapeutic protocol, jointly developed, may accelerate our knowledge and improve our effectiveness in this lethal, if uncommon, disease [49,76,111,170].
基于夸恩的观点和研究结果，提出了一种血栓性血小板减少性紫癜（TTP）发病机制的假说（图8）。通过一系列的推导、推断和扩展，人们试图比以往更严格地定义TTP的临床（表1、2、3）和实验室（表4）特征范式。随着知识的增加，未来可能需要进行修订。通过类似的方法，选择了合理、紧急的治疗措施（表5）。伯恩斯、连及其同事提出的血浆输注创新治疗方法在各方面都与该范式相符。该范式在类似的假性实体中区分出真正的TTP病例。这种隔离将构成一个适合研究的同质病例材料总体。本文定义的TTP范式与联合制定的治疗方案的前瞻性应用，可能会加速我们对这种致命但不常见疾病的认识，并提高我们的治疗效果[49,76,111,170]。
