诺卡氏菌对某些卤代芳香酸的利用。对生长和酶诱导的影响。

Smith A, Tranter E K, Cain R B

Biochem J. 1968 Jan;106(1):203-9. doi: 10.1042/bj1060203.

Halogen analogues of benzoate and p-nitrobenzoate did not support growth of Nocardia erythropolis. 2. These analogues, when present together with the parent compounds, inhibited growth of the organism. 3. The halogen analogues similarly inhibited oxidation of benzoate or p-nitrobenzoate by competent cells. 4. Fluoroacetate and 2-fluoro-4-nitrobenzoate caused comparable inhibition of growth on p-nitrobenzoate and both led to some citrate accumulation. 5. The induction of the p-nitrobenzoate-oxidation system was strongly inhibited by all the 2-halogeno-4-nitrobenzoates although the 2-fluoro and 2-chloro derivatives also acted as inducers. 6. Halogen analogues of benzoate also induced the benzoate-oxidation system.

苯甲酸酯和对硝基苯甲酸酯的卤素类似物不能支持红球诺卡氏菌的生长。2. 这些类似物与母体化合物一起存在时，会抑制该生物体的生长。3. 卤素类似物同样抑制感受态细胞对苯甲酸酯或对硝基苯甲酸酯的氧化。4. 氟乙酸酯和2-氟-4-硝基苯甲酸酯对在对硝基苯甲酸上的生长产生类似的抑制作用，并且两者都会导致一些柠檬酸盐积累。5. 所有2-卤代-4-硝基苯甲酸酯都强烈抑制对硝基苯甲酸氧化系统的诱导，尽管2-氟和2-氯衍生物也可作为诱导剂。6. 苯甲酸酯的卤素类似物也可诱导苯甲酸酯氧化系统。

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核心技术专利：CN118964589B侵权必究

Smith A, Tranter E K, Cain R B

Biochem J. 1968 Jan;106(1):203-9. doi: 10.1042/bj1060203.

Halogen analogues of benzoate and p-nitrobenzoate did not support growth of Nocardia erythropolis. 2. These analogues, when present together with the parent compounds, inhibited growth of the organism. 3. The halogen analogues similarly inhibited oxidation of benzoate or p-nitrobenzoate by competent cells. 4. Fluoroacetate and 2-fluoro-4-nitrobenzoate caused comparable inhibition of growth on p-nitrobenzoate and both led to some citrate accumulation. 5. The induction of the p-nitrobenzoate-oxidation system was strongly inhibited by all the 2-halogeno-4-nitrobenzoates although the 2-fluoro and 2-chloro derivatives also acted as inducers. 6. Halogen analogues of benzoate also induced the benzoate-oxidation system.

苯甲酸酯和对硝基苯甲酸酯的卤素类似物不能支持红球诺卡氏菌的生长。2. 这些类似物与母体化合物一起存在时，会抑制该生物体的生长。3. 卤素类似物同样抑制感受态细胞对苯甲酸酯或对硝基苯甲酸酯的氧化。4. 氟乙酸酯和2-氟-4-硝基苯甲酸酯对在对硝基苯甲酸上的生长产生类似的抑制作用，并且两者都会导致一些柠檬酸盐积累。5. 所有2-卤代-4-硝基苯甲酸酯都强烈抑制对硝基苯甲酸氧化系统的诱导，尽管2-氟和2-氯衍生物也可作为诱导剂。6. 苯甲酸酯的卤素类似物也可诱导苯甲酸酯氧化系统。