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胎儿生长与父母近亲结婚

Fetal growth and parental consanguinity.

作者信息

Sibert J R, Jadhav M, Inbaraj S G

出版信息

Arch Dis Child. 1979 Apr;54(4):317-9. doi: 10.1136/adc.54.4.317.

DOI:10.1136/adc.54.4.317
PMID:572202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1545300/
Abstract

Anthropometric measurements made on 322 newborn infants in South India were related to parental consanguinity. Uncle-niece and first-cousin marriages were common and the average coefficient of inbreeding was as high as 0·0329. The measurements (weight, length, head circumference, and triceps and subscapular skinfold thicknesses) of the uncle-niece groups (52 infants) were smaller than those of the first-cousin group (61 infants) which in turn were smaller than the nonconsanguineous group (196 infants). Statistical significance (P<0·01) was only recorded between the weights of the three groups (means 2650·4, 2794·1, and 2833·8 g) and between the lengths of the uncle-niece group and the nonconsanguineous group (means 46·92 and 47·79 cm). There were no social class or residential differences between the groups. We conclude that there are likely to be recessive genes present in the population, slightly retarding fetal growth.

摘要

对印度南部322名新生儿进行了人体测量,并将其与父母近亲结婚情况相关联。叔侄和表亲婚姻很常见,平均近亲繁殖系数高达0·0329。叔侄组(52名婴儿)的测量值(体重、身长、头围以及肱三头肌和肩胛下皮褶厚度)小于表亲组(61名婴儿),而表亲组又小于非近亲组(196名婴儿)。仅三组体重(均值分别为2650·4、2794·1和2833·8克)之间以及叔侄组与非近亲组的身长(均值分别为46·92和47·79厘米)之间具有统计学显著性(P<0·01)。各组之间不存在社会阶层或居住差异。我们得出结论,该人群中可能存在隐性基因,会略微阻碍胎儿生长。

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本文引用的文献

1
The Effect of Consanguinity on the Distribution of Continuously Variable-Characteristics.近亲结婚对连续可变性状分布的影响。
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THE EFFECTS OF INBREEDING ON GROWTH.近亲繁殖对生长的影响。
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Inbreeding effects on human reproduction in Tamil Nadu of South India.近亲繁殖对印度南部泰米尔纳德邦人类生殖的影响。
Ann Hum Genet. 1977 Jul;41(1):87-98. doi: 10.1111/j.1469-1809.1977.tb01964.x.
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Standards for skinfold thickness in British newborn infants.英国新生儿皮肤褶皱厚度标准。
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Maternal and fetal nutrition in south India.印度南部的母婴营养
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