痘苗病毒的靶体积分析：病毒扩散和非感染性颗粒的影响
Target volume analysis of vaccinia virus: influence of virus dispersion and noninfectious particles.
作者信息
Contreras G, Ohlbaum A
出版信息
J Virol. 1968 Oct;2(10):1102-6. doi: 10.1128/JVI.2.10.1102-1106.1968.
Abstract
These data indicate that 90% of monodisperse vaccinia virus (VV) has a D(37) dose of 1.0 x 10(4) +/- 0.2 x 10(4) rad when exposed to the direct effect of gamma radiation from (137)Cs and (60)Co sources. This D(37) dose yielded a targt size of approximately 10(8) daltons, close to the molecular weight of VV deoxyribonucleic acid. This target corresponds to the first component of the survival curve of VV. Noninfectious virus seemed to play a role on the slope and the proportion of the survival curve second component, suggesting that multiplicity reactivation takes place.
摘要
这些数据表明，当暴露于来自铯 - 137和钴 - 60源的γ辐射的直接作用时，90%的单分散痘苗病毒（VV）的D(37)剂量为1.0×10⁴±0.2×10⁴拉德。该D(37)剂量产生的靶标大小约为10⁸道尔顿，接近VV脱氧核糖核酸的分子量。该靶标对应于VV存活曲线的第一部分。非感染性病毒似乎对存活曲线第二部分的斜率和比例有影响，这表明发生了多重复活。
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