Phillips A D, Rice S J, France N E, Walker-Smith J A
Gut. 1979 Jun;20(6):509-12. doi: 10.1136/gut.20.6.509.
The mean small intestinal intraepithelial lymphocyte count in seven children with untreated cow's milk protein intolerance (CMPI) on a milk-containing diet was significantly higher than 22 control children also having a milk-containing diet. Ten milk-intolerant children on a milk-free diet had a mean intraepithelial lymphocyte count which was significantly lower than the level in the 22 control children on a milk-containing diet. When these 10 children were challenged with cow's milk they relapsed clinically, and in every case the intraepithelial lymphocyte count rose, although it remained within normal limits. Nineteen children on milk-free diets who had recovered from CMPI had a mean lymphocyte count which was also significantly lower than controls on normal diets, suggesting that when milk is remo-ed from the diet the lymphocyte count is low regardless of whether the child is milk sensitive or not. The reaction of intraepithelial lymphocytes to milk in CMPI is markedly different from their response to gluten in coeliac disease.
七名未接受治疗的牛奶蛋白不耐受（CMPI）儿童在食用含牛奶饮食时，其小肠上皮内淋巴细胞平均计数显著高于同样食用含牛奶饮食的22名对照儿童。十名食用无牛奶饮食的牛奶不耐受儿童的上皮内淋巴细胞平均计数显著低于22名食用含牛奶饮食的对照儿童。当这10名儿童接受牛奶激发试验时，他们出现临床复发，且在每种情况下上皮内淋巴细胞计数均升高，尽管仍在正常范围内。19名已从CMPI康复的食用无牛奶饮食儿童的淋巴细胞平均计数也显著低于正常饮食的对照儿童，这表明当从饮食中去除牛奶时，无论儿童是否对牛奶敏感，淋巴细胞计数都会降低。CMPI中上皮内淋巴细胞对牛奶的反应与乳糜泻中它们对麸质的反应明显不同。
