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长期情绪应激在高胆固醇血症和高血压发生中的作用研究。

Investigation of the role of prolonged emotional stress in the genesis of hypercholesteremia and hypertension.

作者信息

Yastrebtsova N L, Simutenko L V

出版信息

Neurosci Behav Physiol. 1978 Jul-Sep;9(3):270-2. doi: 10.1007/BF01187187.

DOI:10.1007/BF01187187
PMID:572925
Abstract

In experiments on freely moving rabbits, exposed to prolonged (for 2 h) interrupted stimulation of negative emotiogenic zones of the hypothalamus through implanted electrodes daily for 4 months, the development of a lasting endogenous hypercholesteremia and of a mild but lasting hypertension was observed. Changes in the cholesterol concentration were greater if stimulation continued in conjunction with daily feeding of the rabbits with small doses of methylthiouracil.

摘要

在对自由活动的兔子进行的实验中,通过植入电极每天对下丘脑的负性情绪发生区进行长时间(2小时)的间断刺激,持续4个月,观察到了持续性内源性高胆固醇血症和轻度但持续性高血压的发展。如果在给兔子每日喂食小剂量甲硫氧嘧啶的同时继续进行刺激,胆固醇浓度的变化会更大。

相似文献

1
Investigation of the role of prolonged emotional stress in the genesis of hypercholesteremia and hypertension.长期情绪应激在高胆固醇血症和高血压发生中的作用研究。
Neurosci Behav Physiol. 1978 Jul-Sep;9(3):270-2. doi: 10.1007/BF01187187.
2
[The role of prolonged emotional stress in the genesis of hypercholesterolemia and hypertension].[长期情绪应激在高胆固醇血症和高血压发生中的作用]
Biull Eksp Biol Med. 1976 Jan;81(1):20-1.
3
[Effect of prolonged chronic stimulation of positive emotionogenic zones of the hypothalamus on blood lipid levels and arterial pressure].[下丘脑正性情绪发生区长期慢性刺激对血脂水平和动脉血压的影响]
Biull Eksp Biol Med. 1981 Jun;91(6):650-2.
4
[Increase in the degree of dietary hypercholesterolemia and the development of stable neurogenic hypertension as affected by the multiple stimulation of the hypothalamic emotive zones].[下丘脑情感区多重刺激对饮食性高胆固醇血症程度增加及稳定型神经源性高血压发展的影响]
Kardiologiia. 1983 Jan;23(1):90-4.
5
[Effect of the chronic stimulation hypothalamic negative emotiogenic zones on a change in blood lipid and heparin content and on arterial pressure].[慢性刺激下丘脑负性情绪发生区对血脂、肝素含量变化及动脉血压的影响]
Kardiologiia. 1978 Jun;18(6):131-6.
6
[Development of atherosclerosis in alternating prolonged electrostimulation of the negative and positive hypothalamic emotiogenic zones].[正负下丘脑情绪发生区交替长时间电刺激下动脉粥样硬化的发展]
Kardiologiia. 1980 Mar;20(3):104-8.
7
[Nature of "congestive" stimulation in emotional stress as a basis of cardiovascular disorders].[作为心血管疾病基础的情绪应激中“充血性”刺激的本质]
Kardiologiia. 1983 Apr;23(4):10-6.
8
[Role of emotional stress in disorders of carbohydrate tolerance].[情绪应激在碳水化合物耐量紊乱中的作用]
Biull Eksp Biol Med. 1983 Apr;95(4):35-7.
9
Acute experimental emotional stress and natural history of arterial hypertension.急性实验性情绪应激与动脉高血压的自然病史
Physiol Behav. 1977 Aug;19(2):213-21. doi: 10.1016/0031-9384(77)90330-4.
10
[Vascular reactivity changes in chronic emotional stress of hypothalamic origin].[下丘脑源性慢性情绪应激中的血管反应性变化]
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1981;4(2):70-4.

本文引用的文献

1
EFFECT OF CHRONIC HYPOTHALAMIC STIMULATION UPON CHOLESTEROL-INDUCED ATHEROSCLEROSIS IN THE RABBIT.慢性下丘脑刺激对兔胆固醇诱导动脉粥样硬化的影响。
J Clin Invest. 1960 Dec;39(12):1963-72. doi: 10.1172/JCI104221.
2
[EMOTIONAL STRESS AS A PREREQUISITE FOR THE DEVELOPMENT OF NEUROGENIC CARDIOVASCULAR DISEASES].[情绪应激作为神经源性心血管疾病发生的先决条件]
Vestn Akad Med Nauk SSSR. 1965;20:10-8.
3
The rabbit diencephalon in stereotaxic coordinates.立体定位坐标下的兔间脑。
J Comp Neurol. 1954 Dec;101(3):801-24. doi: 10.1002/cne.901010307.