Simutenko L V, Iastrebtsova N L, Leontovich T A
Kardiologiia. 1978 Jun;18(6):131-6.
Rabbits kept on a routine diet and subjected, under conditions of free behavior, to long-term chronic (for a period of 4 months) stimulation of hypothalamic zones which give rise to negative emotions had marked stable endogenic hyperlipidemia (hypercholesterolemia, hypertriglyceridemia), a decrease in the blood heparin content, shortening of blood coagulation time, and mild (by 11%) but significant increase of arterial pressure. The extent of these changes differed with the animals. The dynamics of the increase in the blood cholesterol and triglyceride levels differed both in the degree of the increase as compared to the initial levels (by 44 and 74%, respectively) and in the latent period of attaining maximum deviations. There was a definite connection between the changes in the levels of triglycerides and heparin in blood. When rabbits were given small doses of methylthiouracil and stimulation was continued on that background, the blood cholesterol level grew still more (up to 110% of the initial level). The data obtained attest to the role of prolonged emotional stress in the genesis of stable metabolic and vasomotor disorders which may promote the development of preconditions for the origin of such cardiovascular diseases as atherosclerosis, hypertensive disease, and coronary thrombosis.
将常规饮食的兔子在自由活动条件下，对引发负面情绪的下丘脑区域进行长期慢性（为期4个月）刺激后，兔子出现了明显稳定的内源性高脂血症（高胆固醇血症、高甘油三酯血症），血液中肝素含量降低，凝血时间缩短，动脉血压轻度（11%）但显著升高。这些变化的程度因动物个体而异。血液中胆固醇和甘油三酯水平升高的动态变化在与初始水平相比的升高程度（分别为44%和74%）以及达到最大偏差的潜伏期方面都有所不同。血液中甘油三酯水平和肝素水平的变化之间存在一定联系。当给兔子小剂量甲硫氧嘧啶并在此背景下继续进行刺激时，血液胆固醇水平进一步升高（高达初始水平的110%）。所获得的数据证明了长期情绪应激在稳定的代谢和血管舒缩障碍发生过程中的作用，这些障碍可能促进动脉粥样硬化、高血压病和冠状动脉血栓形成等心血管疾病发病前提条件的发展。
