[Effect of the chronic stimulation hypothalamic negative emotiogenic zones on a change in blood lipid and heparin content and on arterial pressure].

Rabbits kept on a routine diet and subjected, under conditions of free behavior, to long-term chronic (for a period of 4 months) stimulation of hypothalamic zones which give rise to negative emotions had marked stable endogenic hyperlipidemia (hypercholesterolemia, hypertriglyceridemia), a decrease in the blood heparin content, shortening of blood coagulation time, and mild (by 11%) but significant increase of arterial pressure. The extent of these changes differed with the animals. The dynamics of the increase in the blood cholesterol and triglyceride levels differed both in the degree of the increase as compared to the initial levels (by 44 and 74%, respectively) and in the latent period of attaining maximum deviations. There was a definite connection between the changes in the levels of triglycerides and heparin in blood. When rabbits were given small doses of methylthiouracil and stimulation was continued on that background, the blood cholesterol level grew still more (up to 110% of the initial level). The data obtained attest to the role of prolonged emotional stress in the genesis of stable metabolic and vasomotor disorders which may promote the development of preconditions for the origin of such cardiovascular diseases as atherosclerosis, hypertensive disease, and coronary thrombosis.