Trulson M E, Jacobs B L
Science. 1979 Sep 21;205(4412):1295-7. doi: 10.1126/science.572992.
Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.
对猫长期给予苯丙胺（平均每日每千克体重8.75毫克，分两次给药，持续10天）导致所检测的所有脑区中血清素及其主要代谢产物5-羟吲哚乙酸大幅下降（40%至67%）。这种处理还产生了几种依赖于中枢血清素能神经传递受抑制的行为，而这些行为通常仅由致幻药物引发。短期给予苯丙胺（15毫克/千克）并未产生这些行为，且导致脑血清素略有下降，而5-羟吲哚乙酸没有变化。这些数据在精神分裂症的单胺理论背景下进行了讨论。
