Owen F, Baker H F, Ridley R M, Cross A J, Crow T J
Psychopharmacology (Berl). 1981;74(3):213-6. doi: 10.1007/BF00427096.
A biochemical study of central dopaminergic mechanisms was carried out in brain tissue from vervet monkeys who had been subjected to chronic amphetamine administration. The brain concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were markedly reduced. Significant reductions were also observed in the activities of dopa-decarboxylase (DDC) and tyrosine hydroxylase (TH). A kinetic study of TH revealed a 60% reduction in maximum reaction velocity, consistent with destruction of DA neurones. However, homovanillic acid (HVA) concentrations were only moderately reduced, suggesting a nearly normal production of DA. Hence despite the large depletions in DA concentrations, high affinity binding of 3H-spiperone binding to striatal DA receptors was no different from controls. The results are discussed in relation to the amphetamine psychosis in humans.
对长期给予苯丙胺的黑长尾猴脑组织进行了中枢多巴胺能机制的生化研究。多巴胺（DA）和3,4-二羟基苯乙酸（DOPAC）的脑内浓度显著降低。多巴脱羧酶（DDC）和酪氨酸羟化酶（TH）的活性也有显著降低。TH的动力学研究显示最大反应速度降低了60%，这与DA神经元的破坏一致。然而，高香草酸（HVA）浓度仅适度降低，提示DA的生成近乎正常。因此，尽管DA浓度大幅降低，但3H-螺哌隆与纹状体DA受体的高亲和力结合与对照组并无差异。结合人类苯丙胺精神病对结果进行了讨论。
