Nesje O A, Enge I
Cardiology. 1979;64(4):241-5. doi: 10.1159/000170621.
The external carotid pulse and the phonocardiogram were recorded in a 48-year-old man with idiopathic hypertrophic subaortic stenosis and atrial fibrillation. The degree of obstruction of left ventricular outflow was assessed by the depth of the mid-systolic dip, the length of the left ventricular ejection time and the intensity of the systolic murmur. The correlation found between the degree of outflow obstruction and the length of the preceeding diastole was interpreted in terms of the Frank-Starling mechanism, i.e. augmented diastolic filling led to an increase in the force of contraction and hence to an increase in muscular obstruction to outflow. The observation that this relationship held also for long diastoles suggested that the left ventricle was not completely filled during diastoles of middle length, probably because of the low diastolic distensibility of the stuff and hypertrophic myocardium.
对一名患有特发性肥厚性主动脉瓣下狭窄和心房颤动的48岁男性记录了颈外动脉脉搏和心音图。通过收缩中期下降的深度、左心室射血时间的长度和收缩期杂音的强度来评估左心室流出道的梗阻程度。根据弗兰克 - 斯塔林机制来解释流出道梗阻程度与前一个舒张期长度之间的相关性，即舒张期充盈增加导致收缩力增加，从而导致肌肉性流出道梗阻增加。这种关系在长舒张期也成立的观察结果表明，在中等长度的舒张期左心室没有完全充盈，可能是因为心肌肥厚且僵硬导致舒张期扩张性低。
