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高动物蛋白摄入量对尿路中钙结石形成风险的影响。

The effect of high animal protein intake on the risk of calcium stone-formation in the urinary tract.

作者信息

Robertson W G, Heyburn P J, Peacock M, Hanes F A, Swaminathan R

出版信息

Clin Sci (Lond). 1979 Sep;57(3):285-8. doi: 10.1042/cs0570285.

DOI:10.1042/cs0570285
PMID:573189
Abstract
  1. Studies were carried out on six normal male subjects to determine the short-term effect of increasing the dietary consumption of animal protein on the urinary risk factors for stone-formation, namely, volume, pH, calcium oxalate, uric acid and glycosaminoglycans. 2. An increase of 34 g/day of animal protein in the diet significantly increased urinary calcium (23%) and oxalate (24%). Total urinary nitrogen increased by an average of 368 mmol/day. The accompanying increase in dietary purine (11 mmol of purine nitrogen/day) caused a 48% increase in the excretion of uric acid. 3. The overall relative probability of forming stones, calculated from a combination of the risk factors, was markedly increased (250%) throughout the period of high animal protein ingestion.
摘要
  1. 对六名正常男性受试者进行了研究,以确定增加动物蛋白饮食摄入量对结石形成的尿液风险因素的短期影响,这些因素包括尿量、pH值、草酸钙、尿酸和糖胺聚糖。2. 饮食中动物蛋白摄入量每天增加34克,显著增加了尿钙(23%)和草酸(24%)。尿总氮平均每天增加368毫摩尔。伴随饮食中嘌呤增加(每天11毫摩尔嘌呤氮),尿酸排泄增加了48%。3. 根据风险因素组合计算得出的结石形成总体相对概率,在高动物蛋白摄入期间显著增加(250%)。

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