Trinchieri A, Mandressi A, Luongo P, Longo G, Pisani E
Institute of Urology, University of Milan, Italy.
Br J Urol. 1991 Mar;67(3):230-6. doi: 10.1111/j.1464-410x.1991.tb15124.x.
The daily intake of 103 recurrent idiopathic calcium stone formers and 146 controls was assessed by means of a computer-assisted 24-h dietary record. Timed 24-h urine samples were collected over the same period to assess the relationship between dietary intake of nutrients and urinary risk factors for calcium stones. After standardisation for sex, age and social status a total of 128 subjects underwent final statistical analysis; 64 renal stone formers and 64 controls. Significant increases in the consumption of animal and vegetable protein and purine were identified as the nutritional factors that distinguished renal stone formers from controls. As expected, the daily urinary excretion of calcium and oxalate was higher and the daily urinary excretion of citrate was lower in stone formers than in controls. No difference with respect to daily urinary uric acid excretion was recorded. Daily urinary excretion of calcium was correlated to dietary protein intake while daily urinary oxalate was correlated to dietary vitamin C intake. It was concluded that renal stone formers could be predisposed to stones because of their dietary patterns. A link between the protein content of the diet and urinary calcium was confirmed, but dietary animal protein had a minimal effect on oxalate excretion.
通过计算机辅助的24小时饮食记录，评估了103名复发性特发性钙结石患者和146名对照者的每日摄入量。在同一时期收集定时的24小时尿液样本，以评估营养素的饮食摄入量与钙结石的尿液危险因素之间的关系。在对性别、年龄和社会地位进行标准化后，共有128名受试者接受了最终的统计分析；64名肾结石患者和64名对照者。动物蛋白、植物蛋白和嘌呤摄入量的显著增加被确定为区分肾结石患者和对照者的营养因素。正如预期的那样，结石患者的每日尿钙和草酸排泄量高于对照者，而每日尿枸橼酸盐排泄量低于对照者。未记录到每日尿酸排泄量的差异。每日尿钙排泄量与饮食蛋白质摄入量相关，而每日尿草酸排泄量与饮食维生素C摄入量相关。得出的结论是，肾结石患者可能因其饮食模式而易患结石。饮食蛋白质含量与尿钙之间的联系得到了证实，但饮食中的动物蛋白对草酸排泄的影响最小。
