Chu N S
Neurology. 1979 Oct;29(10):1397-1401. doi: 10.1212/wnl.29.10.1397.
Effects of carbamazepine on alcohol withdrawal seizures and symptoms were studied in rats. Carbamazepine was administered during alcohol feeding and continued during alcohol withdrawal. When carbamazepine serum levels were above 3 micrograms per milliliter, alcohol withdrawal seizures were not observed. Carbamazepine also alleviated alcohol withdrawal symptoms, especially heightened spontaneous activity, startle to noise, stereotyped chewing movements, and intermittent body stiffening.
在大鼠中研究了卡马西平对酒精戒断性癫痫发作及症状的影响。在给予酒精期间给予卡马西平，并在酒精戒断期间持续给药。当卡马西平血清水平高于每毫升3微克时，未观察到酒精戒断性癫痫发作。卡马西平还减轻了酒精戒断症状，尤其是自发活动增强、对噪音惊吓反应、刻板咀嚼动作以及间歇性身体僵硬。
