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Prevention of alcohol withdrawal seizures with phenytoin in rats.

作者信息

Chu N S

出版信息

Epilepsia. 1981 Apr;22(2):179-84. doi: 10.1111/j.1528-1157.1981.tb04099.x.

DOI:10.1111/j.1528-1157.1981.tb04099.x
PMID:7193576
Abstract

The efficacy of phenytoin in the prevention of alcohol withdrawal seizures was studied in rats. Phenytoin was administrated together with and again 12 hr after the last dose of chronic alcohol feeding. Protection against alcohol withdrawal seizures was not observed when phenytoin serum levels were below 8 micrograms/ml. However, with phenytoin serum levels between 8-25 micrograms/ml, only 1 out of 32 rats had alcohol withdrawal seizures.

摘要

相似文献

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引用本文的文献

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Update on the neurobiology of alcohol withdrawal seizures.酒精戒断性癫痫的神经生物学研究进展。
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