具有预期药理活性的六氢-1,4-硫氮杂䓬衍生物的合成。第一部分。N-烷基（羟烷基）-六氢-1,4-硫氮杂䓬及苯氧乙酸的2-（六氢-1,4-硫氮杂䓬基）乙酯
Synthesis of hexahydro-1,4-thiazepine derivatives with expected pharmacological activity. Part I. N-alkyl(hydroxyalkyl)-hexahydro-1,4-thiazepines and 2-(hexahydro-1,4-thiazepinyl)-ethyl esters of phenoxyacetic acids.
作者信息
Strzelczyk M, Kotełko B
出版信息
Pol J Pharmacol Pharm. 1979 Jan-Feb;31(1):73-82.
PMID:573472
Abstract
New N-alkyl or N-hydroxyalkyl derivatives of hexahydro-1,4-thiazepine(compounds 1--6, Table 2) were obtained by condensation of 2-chloroethyl-3-chloropropyl sulfide with appropriate primary amines. Estrification of 2-hydroxyethylhexahydro-1,4-thiazepine by chloride of appropriate phenoxyacetic acids yielded 2-(hexahydro-1,4-thiazepinyl)-ethyl esters of phenoxyacetic acids (compounds 7--12, Table 4).
摘要
通过2-氯乙基-3-氯丙基硫化物与适当的伯胺缩合，得到了六氢-1,4-硫氮杂卓的新型N-烷基或N-羟烷基衍生物（表2中的化合物1 - 6）。用适当的苯氧乙酸氯化物对2-羟乙基六氢-1,4-硫氮杂卓进行酯化，得到了苯氧乙酸的2-(六氢-1,4-硫氮杂卓基)乙酯（表4中的化合物7 - 12）。
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