Ormond D L, Van Hartesveldt C
Pharmacol Biochem Behav. 1979 Jun;10(6):855-60. doi: 10.1016/0091-3057(79)90057-1.
Dopamine (DA) was injected unilaterally into the dorsal caudate-putamen (D-CPU), ventral caudate-putamen (V-CPU), piriform cortex (PIR), olfactory tubercle (OTU) and frontal cortex (FC) of two day old rats and rotational behavior observed. Injection of DA into D-CPU, PIR, and OTU produced a contralateral postural deviation which differed significantly from the ipsilateral deviation produced by control injections. Only DA injections into PIR and OTU produced contralateral turning differing significantly from the effects of control injections. These results suggest that the DA receptors in C-CPU, PIR, and OTU involved in rotational behavior are functionally mature at two days of age and that the two components of rotation, postural deviation (direction) and turning (locomotion), involve different neural systems at this age. The developing rat is suggested as a valuable tool for understanding the neural circuitry and pharmacology of rotational behavior.
将多巴胺（DA）单侧注射到两日龄大鼠的背侧尾状核-壳核（D-CPU）、腹侧尾状核-壳核（V-CPU）、梨状皮质（PIR）、嗅结节（OTU）和额叶皮质（FC）中，并观察旋转行为。向D-CPU、PIR和OTU注射DA会产生对侧姿势偏差，这与对照注射产生的同侧偏差有显著差异。只有向PIR和OTU注射DA会产生与对照注射效果有显著差异的对侧旋转。这些结果表明，参与旋转行为的C-CPU、PIR和OTU中的DA受体在两日龄时功能已成熟，并且在这个年龄段，旋转的两个组成部分，姿势偏差（方向）和旋转（运动）涉及不同的神经系统。发育中的大鼠被认为是理解旋转行为的神经回路和药理学的有价值工具。
