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鲑鱼降钙素对基础状态及静脉注射葡萄糖负荷后血糖和胰岛素水平的影响。

Effects of salmon calcitonin on blood glucose and insulin levels under basal conditions and after intravenous glucose load.

作者信息

Petralito A, Lunetta M, Liuzzo A, Fiore C E, Heynen G

出版信息

J Endocrinol Invest. 1979 Apr-Jun;2(2):209-11. doi: 10.1007/BF03349315.

DOI:10.1007/BF03349315
PMID:573770
Abstract

A study of the effects of salmon calcitonin (sCT) infusion on blood sugar and serum insulin levels under basal conditions and after intravenous glucose load in normal subjects is reported. Under basal conditions, a 30 min infusion of sCT at approximately a rate of 1 U/min produced a highly significant increase in the blood sugar (p less than 0.01) and a highly significant decrease in the serum insulin levels (p less than 0.01). After intravenous glucose load, there was a decrease of the coefficient of glucose utilization and of the insulin response both of which were highly significant (p less than 0.01).

摘要

本文报道了一项关于鲑鱼降钙素(sCT)输注对正常受试者基础状态下以及静脉注射葡萄糖负荷后血糖和血清胰岛素水平影响的研究。在基础状态下,以约1 U/分钟的速率输注sCT 30分钟,可使血糖显著升高(p<0.01),血清胰岛素水平显著降低(p<0.01)。静脉注射葡萄糖负荷后,葡萄糖利用率系数和胰岛素反应均降低,且两者均具有高度显著性(p<0.01)。

相似文献

1
Effects of salmon calcitonin on blood glucose and insulin levels under basal conditions and after intravenous glucose load.鲑鱼降钙素对基础状态及静脉注射葡萄糖负荷后血糖和胰岛素水平的影响。
J Endocrinol Invest. 1979 Apr-Jun;2(2):209-11. doi: 10.1007/BF03349315.
2
Calcitonin, a diabetogenic hormone?降钙素,一种致糖尿病激素?
J Clin Endocrinol Metab. 1981 Aug;53(2):318-23. doi: 10.1210/jcem-53-2-318.
3
The effect of calcitonin on glucose metabolism.降钙素对葡萄糖代谢的影响。
Endokrinologie. 1976;68(2):226-30.
4
Synthetic salmon calcitonin is not diabetogenic in patients with normal or impaired glucose metabolism.合成鲑鱼降钙素对葡萄糖代谢正常或受损的患者不具有致糖尿病作用。
J Endocrinol Invest. 1985 Feb;8(1):19-23. doi: 10.1007/BF03350629.
5
The effects of calcitonin, somatostatin and hypercalcaemia on metabolic and hormonal indicators during an oral glucose tolerance test (OGTT).降钙素、生长抑素和高钙血症对口服葡萄糖耐量试验(OGTT)期间代谢和激素指标的影响。
Exp Clin Endocrinol. 1987 Mar;89(1):91-6. doi: 10.1055/s-0029-1210632.
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Oral salmon calcitonin enhances insulin action and glucose metabolism in diet-induced obese streptozotocin-diabetic rats.口服鲑鱼降钙素增强饮食诱导肥胖链脲佐菌素糖尿病大鼠的胰岛素作用和葡萄糖代谢。
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Effect of calcitonin on insulin response to arginine in man.
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引用本文的文献

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Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases.胰淀素、降钙素和 CGRP 受体的单激动剂和双激动剂及其在代谢性疾病中的潜在作用。
Mol Metab. 2021 Apr;46:101109. doi: 10.1016/j.molmet.2020.101109. Epub 2020 Nov 7.
2
Effects of calcium and calcitonin on circulating levels of glucagon and glucose in diabetes mellitus.钙和降钙素对糖尿病患者胰高血糖素和血糖循环水平的影响。
Diabetologia. 1981 May;20(5):547-52. doi: 10.1007/BF00252763.
3
Effects of synthetic salmon calcitonin administration on gastrin, immunoreactive insulin and growth hormone release after protein meal in uremic patients.

本文引用的文献

1
Isolation and chemical properties of two calcitonins from salmon ultimobranchial glands.从鲑鱼后鳃腺中分离出两种降钙素及其化学性质
J Biol Chem. 1970 Mar 25;245(6):1491-6.
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Coated charcoal immunoassay of insulin.胰岛素的包被炭免疫测定法。
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3
The stimulus-secretion coupling of glucose-induced insulin release. V. The participation of a microtubular-microfilamentous system.葡萄糖诱导胰岛素释放的刺激-分泌偶联。V. 微管-微丝系统的参与
J Endocrinol Invest. 1981 Apr-Jun;4(2):185-8. doi: 10.1007/BF03350449.
4
Pharmacology and therapeutic use of calcitonin.降钙素的药理学与治疗用途。
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Calcitonin and insulin secretion in normal man: study with somatostatin and calcium.正常人体内降钙素与胰岛素的分泌:使用生长抑素和钙的研究
Acta Diabetol Lat. 1983 Jan-Mar;20(1):41-6. doi: 10.1007/BF02629128.
6
Synthetic salmon calcitonin is not diabetogenic in patients with normal or impaired glucose metabolism.合成鲑鱼降钙素对葡萄糖代谢正常或受损的患者不具有致糖尿病作用。
J Endocrinol Invest. 1985 Feb;8(1):19-23. doi: 10.1007/BF03350629.
7
Effect of human calcitonin (hCT) on glucose- and arginine-stimulated insulin secretion.人降钙素(hCT)对葡萄糖和精氨酸刺激的胰岛素分泌的影响。
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Diabetes. 1971 May;20(5):257-65. doi: 10.2337/diab.20.5.257.
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Beta cell secretion--from the standpoint of a pathobiologist.β细胞分泌——从病理生物学家的角度来看
Diabetes. 1970 Dec;19(12):895-905. doi: 10.2337/diab.19.12.895.
5
Requirement for calcium ion in insulin secretion by the perfused rat pancreas.灌注大鼠胰腺胰岛素分泌中钙离子的需求
Am J Physiol. 1968 Jan;214(1):174-8. doi: 10.1152/ajplegacy.1968.214.1.174.
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A study of the stability of calcitonin biological activity.降钙素生物活性稳定性的研究
Endocrinology. 1973 Apr;92(4):1102-6. doi: 10.1210/endo-92-4-1102.
7
[Influence of calcitonin on insulin secretion after intravenous administration of glucose].[降钙素对静脉注射葡萄糖后胰岛素分泌的影响]
G Clin Med. 1974 May;55(5):362-70.
8
Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.体外分离大鼠胰岛的灌流。微管系统在胰岛素双相释放中的作用。
Diabetes. 1972 Oct;21(10):987-98. doi: 10.2337/diab.21.10.987.
9
Insulin biosynthesis and secretion--a still unsettled topic.胰岛素的生物合成与分泌——一个仍未解决的课题。
N Engl J Med. 1970 Jan 22;282(4):173-82. doi: 10.1056/NEJM197001222820401.