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DNA与卟啉配体的相互作用:嵌入作用的证据。

Interaction of DNA with a porphyrin ligand: evidence for intercalation.

作者信息

Fiel R J, Howard J C, Mark E H, Datta Gupta N

出版信息

Nucleic Acids Res. 1979 Jul 11;6(9):3093-118. doi: 10.1093/nar/6.9.3093.

Abstract

The porphyrin photosensitizer, meso-Tetra (4-N-methylpyridyl) porphine tetraperchlorate binds to calf thymus DNA by intercalation and by external electrostatic association. This was concluded from the results of measruements involving Scatchard analysis, viscometry, thermal denaturation, and circular dichroism.

摘要

卟啉光敏剂,中-四(4-N-甲基吡啶基)卟啉四高氯酸盐通过嵌入和外部静电缔合作用与小牛胸腺DNA结合。这是通过涉及斯卡查德分析、粘度测定、热变性和圆二色性的测量结果得出的结论。

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Aggregation of properties of water-soluble porphyrins.
Ann N Y Acad Sci. 1973;206:614-30. doi: 10.1111/j.1749-6632.1973.tb43240.x.
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Studies on the Methyl Green-DNA complex and its dissociation by drugs.
Biochemistry. 1975 Nov 18;14(23):5061-7. doi: 10.1021/bi00694a005.
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Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light.
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Radiation modifying effects of meso-tetraphenyl porphyrins.
Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):65-76.
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