中位-四（4-N-甲基吡啶基）卟啉与DNA的结合
Binding of meso-tetra (4-N-methylpyridyl) porphine to DNA.
作者信息
Fiel R J, Munson B R
出版信息
Nucleic Acids Res. 1980 Jun 25;8(12):2835-42. doi: 10.1093/nar/8.12.2835.
Abstract
The porphyrin photosensitizer, meso-Tetra (4-N-methyl-pyridyl) porphine tetraperchlorate is shown to unwind supercoiled ColEI DNA at a somewhat lower concentration than ethidium bromide. In contrast to this, the Fe(III) chelate of T4MPyP cannot unwind supercoiled DNA. It is concluded that these results corroborate our previous findings that, despite its large bulk, T4MPyP is fully capable of intercalating in DNA.
摘要
卟啉光敏剂，即中-四（4-N-甲基吡啶基）卟啉四高氯酸盐，在比溴化乙锭稍低的浓度下就能使超螺旋ColE1 DNA解旋。与此相反，T4MPyP的Fe(III)螯合物不能使超螺旋DNA解旋。由此得出结论，这些结果证实了我们之前的发现，即尽管T4MPyP体积庞大，但它完全能够嵌入DNA中。
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