Drust E G, Sloviter R S, Connor J D
Pharmacology. 1979;18(6):299-305. doi: 10.1159/000137269.
Intraventricular administration of serotonin to rats causes 'wet-dog' shakes, a sign of morphine withdrawal. The frequency of shakes is dose-dependent. Shaking is potentiated by pretreatment with an inhibitor of monoamine oxidase or with 5,7-dihydroxytryptamine, and is depressed by morphine or serotonin receptor blockers. Depression of serotonin-induced shaking by morphine is reversed rapidly by naloxone. However, naloxone did not reverse the inhibition of 'wet-dog' shakes caused by serotonin receptor blockers.
向大鼠脑室内注射血清素会引发“湿狗”颤抖，这是吗啡戒断的一种表现。颤抖频率呈剂量依赖性。单胺氧化酶抑制剂或5,7 - 二羟基色胺预处理可增强颤抖，而吗啡或血清素受体阻滞剂则会抑制颤抖。吗啡对血清素诱导的颤抖的抑制作用可被纳洛酮迅速逆转。然而，纳洛酮并不能逆转血清素受体阻滞剂对“湿狗”颤抖的抑制作用。
