Kruszewska A, Langwiński R
Drug Alcohol Depend. 1983 Nov;12(3):273-8. doi: 10.1016/0376-8716(83)90070-4.
It was found that 200 mg/kg of DL-p-chlorophenylalanine (PCPA) and 2 mg/kg of methergoline drugs inhibiting central serotoninergic transmission-decreased naloxone precipitated abstinence wet dog shakes in morphine-dependent rats. The inhibitory effect of PCPA was reversed by 200 mg/kg of 5-hydroxy-L-tryptophan (5-HTP) but not by the same amount of L-tryptophan (TP). 5-HTP alone (200 mg/kg) increased wet dog shakes epissodes, whereas TP alone in the same dosage practically did not have any influence on the wet dog shakes in morphine-dependent rats. These findings suggest that brain serotonin may play some role in the expression of wet dog shakes in morphine-dependent rats.
研究发现，200毫克/千克的DL-对氯苯丙氨酸（PCPA）和2毫克/千克的美麦角林这两种抑制中枢5-羟色胺能传递的药物，可减少吗啡依赖大鼠中纳洛酮诱发的戒断性湿狗样抖动。PCPA的抑制作用可被200毫克/千克的5-羟-L-色氨酸（5-HTP）逆转，但同等剂量的L-色氨酸（TP）则不能。单独使用5-HTP（200毫克/千克）会增加湿狗样抖动发作次数，而相同剂量的TP单独使用对吗啡依赖大鼠的湿狗样抖动几乎没有任何影响。这些发现表明，脑内5-羟色胺可能在吗啡依赖大鼠的湿狗样抖动表达中发挥一定作用。
