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1
Medium-chain fatty acid synthesis in lactating-rabbit mammary gland. Intracellular concentration and specificity of medium-chain acyl thioester hydrolase.泌乳兔乳腺中中链脂肪酸的合成。中链酰基硫酯水解酶的细胞内浓度及特异性。
Biochem J. 1979 Aug 1;181(2):267-74. doi: 10.1042/bj1810267.
2
Fatty-acid synthesis in lactating-goat mammary gland. 2. Medium-chain fatty acid synthesis.泌乳山羊乳腺中的脂肪酸合成。2. 中链脂肪酸合成。
Eur J Biochem. 1979 Apr;95(3):503-7. doi: 10.1111/j.1432-1033.1979.tb12990.x.
3
Immunological properties of medium-chain acyl-thioester hydrolase and fatty acid synthetase from lactating-rabbit mammary gland.泌乳兔乳腺中链酰基硫酯水解酶和脂肪酸合成酶的免疫学特性
Biochim Biophys Acta. 1977 May 25;487(2):361-7. doi: 10.1016/0005-2760(77)90012-1.
4
Purification and some properties of a medium-chain acyl-thioester hydrolase from lactating-rabbit mammary gland which terminates chain elongation in fatty acid synthesis.来自泌乳兔乳腺的一种中链酰基硫酯水解酶的纯化及其某些特性，该酶可终止脂肪酸合成中的链延伸。
Biochem J. 1976 Dec 15;160(3):683-91. doi: 10.1042/bj1600683.
5
Medium-chain fatty acyl-s-4'-phosphopantetheine-fatty acid synthase thioester hydrolase from lactating rabbit and goat mammary glands.来自泌乳兔和山羊乳腺的中链脂肪酰基-s-4'-磷酸泛酰巯基乙胺-脂肪酸合酶硫酯水解酶
Methods Enzymol. 1981;71 Pt C:200-29. doi: 10.1016/0076-6879(81)71028-0.
6
Medium chain acyl-thioester hydrolase activity in goat and rabbit mammary gland fatty acid synthetase complexes.山羊和兔乳腺脂肪酸合成酶复合物中的中链酰基硫酯水解酶活性
Biochem Biophys Res Commun. 1978 Feb 28;80(4):745-9. doi: 10.1016/0006-291x(78)91308-6.
7
Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of medium-chain-length (C8-C12) acyl-CoA esters by goat mammary-gland fatty acid synthetase.转酰基作用作为哺乳动物脂肪酸合成酶催化脂肪酸合成过程中的链终止机制。山羊乳腺脂肪酸合成酶催化中链长度（C8 - C12）酰基辅酶A酯的合成。
Biochem J. 1982 Jan 15;202(1):139-43. doi: 10.1042/bj2020139.
8
The role of soluble acyl-thioester hydrolase in fatty acid chain-length termination in rabbit mammary gland and liver.可溶性酰基硫酯水解酶在兔乳腺和肝脏脂肪酸链长度终止中的作用。
Adv Exp Med Biol. 1978;101:27-36. doi: 10.1007/978-1-4615-9071-2_3.
9
The interaction of fatty acid synthetase with cytoplasmic protein in the control of the chain-length of fatty acids synthesised by the lactating rabbit mammary gland.脂肪酸合成酶与细胞质蛋白在泌乳兔乳腺合成脂肪酸链长度控制中的相互作用。
Biochim Biophys Acta. 1976 Jan 18;486(1):91-102. doi: 10.1016/0005-2760(77)90073-x.
10
Medium-chain fatty acid synthesis by goat mammary-gland fatty acid synthetase. The effect of limited proteolysis.山羊乳腺脂肪酸合成酶合成中链脂肪酸。有限蛋白酶解的影响。
Biochem J. 1983 Jan 1;209(1):215-22. doi: 10.1042/bj2090215.

引用本文的文献

1
Depletion of acyl-coenzyme A-binding protein affects sphingolipid synthesis and causes vesicle accumulation and membrane defects in Saccharomyces cerevisiae.酰基辅酶A结合蛋白的缺失影响鞘脂合成，并导致酿酒酵母中的囊泡积累和膜缺陷。
Mol Biol Cell. 2001 Apr;12(4):1147-60. doi: 10.1091/mbc.12.4.1147.
2
Construction of the complete rat fatty acid synthase cDNA and its expression in Saccharomyces cerevisiae.大鼠脂肪酸合酶全长cDNA的构建及其在酿酒酵母中的表达。
Curr Genet. 1996 Feb;29(3):219-26. doi: 10.1007/BF02221551.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
[On the biosynthesis of fatty acids. II. Synthesis and properties of S-malonyl-coenzyme A].[关于脂肪酸的生物合成。II. S-丙二酰辅酶A的合成与性质]
Biochem Z. 1962;335:540-7.
3
The relationship between palmitoyl-coenzyme A synthetase activity and esterification of sn-glycerol 3-phosphate in rat liver mitochondria.大鼠肝脏线粒体中棕榈酰辅酶A合成酶活性与sn-甘油3-磷酸酯化作用之间的关系
Biochem J. 1973 Apr;132(4):697-706. doi: 10.1042/bj1320697.
4
The pattern of fatty acid synthesis in lactating rabbit mammary gland studied in vivo.在体内研究泌乳兔乳腺中脂肪酸合成的模式。
Biochem J. 1972 Feb;126(4):1005-7. doi: 10.1042/bj1261005.
5
Fatty acid synthetase from cow mammary gland tissue cells.来自奶牛乳腺组织细胞的脂肪酸合成酶。
Biochim Biophys Acta. 1972 Nov 30;280(3):408-14. doi: 10.1016/0005-2760(72)90246-9.
6
The concentration of malonyl-coenzyme A and the control of fatty acid synthesis in vivo.丙二酰辅酶A的浓度与体内脂肪酸合成的调控
J Biol Chem. 1972 Nov 25;247(22):7325-31.
7
[Synthesis of various carboxylic acids by the fatty acid synthetase multienzyme complex of yeast and the explanation for their structure].[酵母脂肪酸合成多酶复合体合成各种羧酸及其结构解析]
Eur J Biochem. 1969 Sep;10(2):377-87. doi: 10.1111/j.1432-1033.1969.tb00701.x.
8
The purification and properties of the fatty acid synthetase of pigeon liver.鸽肝脂肪酸合成酶的纯化及性质
J Biol Chem. 1965 Oct;240(10):3736-46.
9
Immunization, isolation of immunoglobulins, estimation of antibody titre.免疫接种、免疫球蛋白的分离、抗体滴度的测定。
Scand J Immunol Suppl. 1973;1:161-4. doi: 10.1111/j.1365-3083.1973.tb03798.x.
10
Regulation of fatty-acid synthesis in higher animals.高等动物中脂肪酸合成的调控。
Ergeb Physiol. 1974;69(0):54-96.

泌乳兔乳腺中中链脂肪酸的合成。中链酰基硫酯水解酶的细胞内浓度及特异性。

Medium-chain fatty acid synthesis in lactating-rabbit mammary gland. Intracellular concentration and specificity of medium-chain acyl thioester hydrolase.

作者信息

Knudsen J

出版信息

Biochem J. 1979 Aug 1;181(2):267-74. doi: 10.1042/bj1810267.

DOI:10.1042/bj1810267
PMID:574008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161158/
Abstract

The concentration of medium-chain acyl thioester hydrolase and of fatty acid synthetase was determined by rocket immunoelectrophoresis in nine different particle-free supernatant fractions from lactating-rabbit mammary gland. The molar ratio of the hydrolase to fatty acid synthetase was 1.99 +/- 0.66 (mean +/- S.D.). A rate-limiting concentration of malonyl-CoA was required to ensure the predominant synthesis of medium-chain fatty acids when 2 mol of the hydrolase was added per mol of fatty acid synthetase. The interaction of the hydrolase with fatty acid synthetase was concentration-dependent, though an optimum concentration of hydrolase to synthetase could not be obtained. The lactating-rabbit mammary gland hydrolase altered the pattern of fatty acids synthesized by fatty acid synthetases prepared from cow, goat, sheep and rabbit lactating mammary glands, rabbit liver and cow adipose tissue.

摘要

通过火箭免疫电泳法测定了来自泌乳兔乳腺的九个不同无颗粒上清液组分中中链酰基硫酯水解酶和脂肪酸合成酶的浓度。水解酶与脂肪酸合成酶的摩尔比为1.99±0.66（平均值±标准差）。当每摩尔脂肪酸合成酶添加2摩尔水解酶时，需要丙二酰辅酶A的限速浓度以确保主要合成中链脂肪酸。水解酶与脂肪酸合成酶的相互作用是浓度依赖性的，尽管无法获得水解酶与合成酶的最佳浓度。泌乳兔乳腺水解酶改变了由牛、山羊、绵羊和兔泌乳乳腺、兔肝脏和牛脂肪组织制备的脂肪酸合成酶所合成的脂肪酸模式。