泌乳山羊乳腺中的脂肪酸合成。2. 中链脂肪酸合成。
Fatty-acid synthesis in lactating-goat mammary gland. 2. Medium-chain fatty acid synthesis.
作者信息
Grunnet I, Knudsen J
出版信息
Eur J Biochem. 1979 Apr;95(3):503-7. doi: 10.1111/j.1432-1033.1979.tb12990.x.
Addition of goat, rat, rabbit and cow mammary microsomal fraction to fatty acid synthetase of goat mammary gland induced C10 fatty acid synthesis. When the microsomal fractions from rat, rabbit and cow mammary gland were incubated with their respective fatty acid synthetases only the cow enzyme synthesized significant amounts of C10 compared to the purified fatty acid synthetases alone. The goat mammary microsomal fraction was not able to induce C10 synthesis by rat and rabbit mammary-gland fatty acid synthetase, but only by the goat and cow enzyme. Both goat and cow mammary-gland fatty acid synthetase have in contrast to the rabbit and rat enzymes the ability to hydrolyse medium-chain acyl-thioesters. We therefore suggest a novel mechanism for medium-chain fatty acid synthesis in lactating-goat mammary gland. This mechanism involves an activation of the medium-chain acyl-thioester hydrolase within the fatty acid synthetase of goat mammary gland by an unknown microsomal factor.
向山羊乳腺脂肪酸合成酶中添加山羊、大鼠、兔子和奶牛的乳腺微粒体部分可诱导C10脂肪酸合成。当将大鼠、兔子和奶牛乳腺的微粒体部分与它们各自的脂肪酸合成酶一起孵育时，与单独的纯化脂肪酸合成酶相比，只有奶牛的酶能合成大量的C10。山羊乳腺微粒体部分不能通过大鼠和兔子乳腺脂肪酸合成酶诱导C10合成，而只能通过山羊和奶牛的酶。与兔子和大鼠的酶相比，山羊和奶牛乳腺脂肪酸合成酶都具有水解中链酰基硫酯的能力。因此，我们提出了一种泌乳山羊乳腺中链脂肪酸合成的新机制。该机制涉及山羊乳腺脂肪酸合成酶中的中链酰基硫酯水解酶被一种未知的微粒体因子激活。
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