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[应激遗传学中的问题。IV. 大鼠情绪应激中自主反应性水平的遗传分析]

[Problems in the genetics of stress. IV. A genetic analysis of the level of autonomic reactivity in emotional stress in rats].

作者信息

Osadchuk A V, Markel' A L, Khusainov R A, Naumenko E V, Beliaev D K

出版信息

Genetika. 1979;15(10):1847-57.

PMID:574106
Abstract

A genetic analysis of hypertensive reactions under condition of emotional stress in three inbred strains of rats (Wistar, Sprague-Dowly and August) and their F1 reciprocal hybrids is carried out. Highly significant genotypic differences in the arterial pressure level during emotional stress and no genetic diversity in the basal state were found. Application of our own methos to genetic analysis of incomplete diallelic tables for Griffing's experimental design 1 (model 1) showed an existence of significant additive component of genetic variance in autonomic reactivity under the stress. The role of the stress as a factor of differentiation of the genetic structure of population is discussed.

摘要

对三种近交系大鼠(Wistar、Sprague-Dowly和August)及其F1正反交杂种在情绪应激条件下的高血压反应进行了遗传分析。发现情绪应激期间动脉压水平存在高度显著的基因型差异,而基础状态下无遗传多样性。应用我们自己的方法对Griffing实验设计1(模型1)的不完全双列杂交表进行遗传分析,结果表明应激状态下自主反应性的遗传方差存在显著的加性成分。讨论了应激作为群体遗传结构分化因素的作用。

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