Mostow S R, Dreisin R B, Manawadu B R, LaForce F M
Laryngoscope. 1979 Oct;89(10 Pt 1):1697-701. doi: 10.1002/lary.5540891019.
The effect of standard concentrations of lidocaine HCl and methylparaben (preservative) on the ciliary activity of ferret tracheal rings in organ culture was assessed. Pure lidocaine concentrations as low as 0.5% caused complete ciliostasis which was reversible after removal of the drug. One percent and two percent effects were not completely reversible. Pure methylparaben concentrations as low as 0.06 mg/ml paralyzed cilia; and, at concentrations of 0.5 mg/ml or higher, adverse effects were not completely reversible. When lidocaine and methylparaben were combined at the same ratio used in commercial preparations, their ciliotoxic effects were additive. These data suggest that topical respiratory anesthesia may result in prolonged ciliary paralysis.
评估了标准浓度的盐酸利多卡因和对羟基苯甲酸甲酯（防腐剂）对雪貂气管环在器官培养中的纤毛活动的影响。低至0.5%的纯利多卡因浓度可导致完全的纤毛运动停止，在去除药物后这种情况是可逆的。1%和2%的浓度产生的影响则不完全可逆。低至0.06 mg/ml的纯对羟基苯甲酸甲酯浓度会使纤毛麻痹；而在0.5 mg/ml或更高浓度时，不良反应不完全可逆。当利多卡因和对羟基苯甲酸甲酯以商业制剂中使用的相同比例混合时，它们的纤毛毒性作用是相加的。这些数据表明局部呼吸道麻醉可能导致纤毛麻痹时间延长。
