Roth Y, Aharonson E F, Teichtahl H, Baum G L, Priel Z, Modan M
Department of Polymer Research Weizmann Institute of Science, Rehovot, Israel.
Ann Otol Rhinol Laryngol. 1991 May;100(5 Pt 1):378-84. doi: 10.1177/000348949110000506.
In vitro nasal and tracheal ciliary beat frequencies (CBFs) were measured photometrically in brush samples of 15 patients undergoing bronchoscopy. Tracheal and nasal CBF values in these patients were found to be significantly correlated (r = .74, p less than .01), and the latter did not differ significantly from the nasal CBF of 80 subjects serving as controls. Premedication with morphine and atropine and local anesthesia with lidocaine hydrochloride significantly decreased the CBF. Among the control subjects, a significantly higher CBF (13.6 +/- 1.5 Hz) was found in the young age group (10 to 19 years) as compared to other groups (12.2 +/- 1.7 Hz). Gender and ethnic origin did not influence CBF in any age group. These data support the possible use of the in vitro study of nasal epithelium to reflect the CBF in the lower respiratory tract.
对15例接受支气管镜检查患者的刷检样本进行光度测量，以测定体外鼻腔和气管的纤毛摆动频率（CBF）。发现这些患者的气管和鼻腔CBF值显著相关（r = 0.74，p小于0.01），且后者与80名作为对照的受试者的鼻腔CBF无显著差异。吗啡和阿托品预处理以及盐酸利多卡因局部麻醉显著降低了CBF。在对照受试者中，与其他组（12.2±1.7Hz）相比，年轻年龄组（10至19岁）的CBF显著更高（13.6±1.5Hz）。性别和种族在任何年龄组中均不影响CBF。这些数据支持通过体外研究鼻腔上皮来反映下呼吸道CBF的可能性。
