Manawadu B R, Mostow S R, LaForce F M
Anesth Analg. 1979 Nov-Dec;58(6):500-4.
The effects of varying concentrations of halothane on tracheal ciliary activity were studied using a ferret tracheal organ culture technique. Using 1% and 2% halothane produced no impairment of ciliary activity, while 3% halothane caused some ciliostasis; 4% and 5% halothane produced rapid cessation of ciliary activity. Recovery was prompt and complete after exposure to 4% halothane for as long as 3 days, but after 4 days of exposure recovery was incomplete and after a week of exposure death of ciliary cells occurred.
采用雪貂气管器官培养技术，研究了不同浓度氟烷对气管纤毛活动的影响。使用1%和2%的氟烷不会损害纤毛活动，而3%的氟烷会导致一定程度的纤毛运动停滞；4%和5%的氟烷会使纤毛活动迅速停止。暴露于4%氟烷长达3天后，恢复迅速且完全，但暴露4天后恢复不完全，暴露一周后纤毛细胞死亡。
