Morelli M, Porceddu M L, Di Chiara G
Brain Res. 1980 Jun 2;191(1):67-78. doi: 10.1016/0006-8993(80)90315-7.
Fifteen days after bilateral lesions of the substantia nigra by local infusion of kainic acid (0.75 microgram) or after intranigral injection of vehicle, rats were administered 0.1, 0.25, 1.0 and 2.5 mg/kg s.c. of apomorphine and the stereotyped items (locomotion, sniffing and gnawing) were recorded on an event-recorder and motility was measured by a photocell apparatus. After low doses of apomorphine (0.1, 0.2 mg/kg), rats lesioned in the substantia nigra with kainic acid showed a degree of stimulation of motility and of sniffing similar to controls; on the other hand, in rats lesioned with kainic acid in the nigra, a dramatic reduction of gnawing and its replacement by sniffing was observed after administration of higher doses of apomorphine (1.0, 2.5 mg/kg). Bilateral infusion of kainic acid (0.75 microgram) into the reticular information, 2.0 mm dorsal to the substantia nigra, had no effect on apomorphine-induced stereotyped behaviour. These results are in agreement with the concept that the substantia nigra, through non-DA pars reticulata neurons, mediates motor and behavioural syndromes of striatal origin.
通过局部注入 kainic 酸（0.75 微克）对黑质进行双侧损伤 15 天后，或在黑质内注射赋形剂后，给大鼠皮下注射 0.1、0.25、1.0 和 2.5 毫克/千克的阿扑吗啡，并在事件记录器上记录刻板行为（运动、嗅探和啃咬），并通过光电管装置测量运动能力。在低剂量阿扑吗啡（0.1、0.2 毫克/千克）作用下，用 kainic 酸损伤黑质的大鼠表现出与对照组相似程度的运动和嗅探刺激；另一方面，在黑质用 kainic 酸损伤的大鼠中，给予较高剂量阿扑吗啡（1.0、2.5 毫克/千克）后，观察到啃咬显著减少并被嗅探取代。向黑质背侧 2.0 毫米处的网状结构双侧注入 kainic 酸（0.75 微克）对阿扑吗啡诱导的刻板行为没有影响。这些结果与以下概念一致，即黑质通过非多巴胺网状部神经元介导纹状体起源的运动和行为综合征。
