天然抗肿瘤药物的微生物转化：弯孢菌将拉帕醇转化为脱氢-α-拉帕醌
Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata.
作者信息
Otten S, Rosazza J P
出版信息
Appl Environ Microbiol. 1979 Aug;38(2):311-3. doi: 10.1128/aem.38.2.311-313.1979.
Abstract
Microbial transformation of lapachol, a naturally occurring naphthoquinone, was carried out by Curvularia lunata (NRRL 2178). The fungus brings about oxidative cyclization of the substrate to dehydro-alpha-lapachone, which was isolated and characterized by nuclear magnetic resonance and mass spectral analyses; its structure was verified by chemical synthesis. The metabolite is a naturally occurring chromene possessing antibacterial and antitumor activities.
摘要
弯孢霉（NRRL 2178）对天然存在的萘醌拉帕醇进行了微生物转化。该真菌使底物发生氧化环化反应生成脱氢-α-拉帕醌，后者经分离并通过核磁共振和质谱分析进行了表征；其结构通过化学合成得以验证。该代谢产物是一种天然存在的具有抗菌和抗肿瘤活性的色烯。
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Appl Environ Microbiol. 1978 Mar;35(3):554-7. doi: 10.1128/aem.35.3.554-557.1978.
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