Rosazza J P, Nicholas A W, Gustafson M E
Steroids. 1978 May;31(5):671-9. doi: 10.1016/s0039-128x(78)80007-5.
Microbial transformation experiments were conducted with the steroidlactone, withaferin-A (1a). Cunninghamella elegans (NRRL 1393) converts withaferin-A into two major metabolites, one of which has been indentified as 14alpha-hydroxywithaferin-A (1b). The metabolite is obtained in 37% yield, and its structure was determined on the basis of pmr and mass spectral evidence. The metabolite has the same level of antitumor activity as withaferin-A against the Sarcoma-180 tumor test system in mice.
对甾体内酯阿魏酸 A（1a）进行了微生物转化实验。雅致小克银汉霉（NRRL 1393）将阿魏酸 A 转化为两种主要代谢产物，其中一种已被鉴定为 14α-羟基阿魏酸 A（1b）。该代谢产物的产率为 37%，其结构是根据核磁共振氢谱（pmr）和质谱证据确定的。在小鼠肉瘤 180 肿瘤测试系统中，该代谢产物具有与阿魏酸 A 相同水平的抗肿瘤活性。
