天然抗肿瘤剂的微生物转化：青霉对拉帕醇的氧化作用。
Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.
作者信息
Otten S, Rosazza J P
出版信息
Appl Environ Microbiol. 1978 Mar;35(3):554-7. doi: 10.1128/aem.35.3.554-557.1978.
Abstract
The naphthoquinone lapachol (1) is readily metabolized by several fungi and streptomycetes. Preparative-scale fermentations with Penicillium notatum (UI 1602) provided a major polar metabolite (4), which was isolated and identified as an intermediate of the Hooker oxidation. The metabolite was synthesized by reacting lapachol with hydrogen peroxide under alkaline conditions.
摘要
萘醌拉帕醇（1）很容易被几种真菌和链霉菌代谢。用点青霉（UI 1602）进行的制备规模发酵产生了一种主要的极性代谢物（4），该代谢物被分离并鉴定为胡克氧化反应的中间体。该代谢物是通过在碱性条件下使拉帕醇与过氧化氢反应合成的。
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