Pap A, Lechene de la Porte P, Sarles H
Pflugers Arch. 1979 Dec;383(1):19-27. doi: 10.1007/BF00584470.
The effects of stepwise increasing doses of intravenous caerulein, secretin, urecholine and intraduodenal oleic acid were investigated in conscious rats. a) Basal water, bicarbonate, and protein secretion significantly augmented after diversion of pancreatic juice. On the basis of protein secretory pattern of basal secretion 3 stable stages have been recognised: 1. The most physiological basal stage during return of pancreatic juice. 2. The first, highly elevated plateau from the 4th to 7th 30-min period after diversion of pancreatic juice. 3. The second, delayed and less elevated plateau after 270 min. b) The following patterns of stimulated secretion were observed: 1. Caerulein stimulated protein and bicarbonate secretion during return of juice and the first plateau but it failed to elicit a significant response during the second, delayed plateau. 2. Secretin and urecholine showed similar protein responses during return of pancreatic juice but after diversion, they stimulated water and bicarbonate secretion only. 3. During the second plateau oleic acid stimulation resulted in a significant increase in water and bicarbonate secretion but no significant increase occured in protein output. The delayed inhibition of protein secretion, previously described in our laboratory, was unchanged. 4. Supramaximal doses of exogenous stimuli caused an inhibition in pancreatic secretion.
在清醒大鼠中研究了静脉注射递增剂量的蛙皮素、促胰液素、乌拉胆碱以及十二指肠内注入油酸的作用。a）胰液改道后，基础水、碳酸氢盐和蛋白质分泌显著增加。根据基础分泌的蛋白质分泌模式，已识别出3个稳定阶段：1. 胰液回流期间最具生理性的基础阶段。2. 胰液改道后第4至第7个30分钟期间的第一个高度升高的平台期。3. 270分钟后的第二个延迟且升高程度较小的平台期。b）观察到以下刺激分泌模式：1. 蛙皮素在胰液回流和第一个平台期刺激蛋白质和碳酸氢盐分泌，但在第二个延迟平台期未能引发显著反应。2. 促胰液素和乌拉胆碱在胰液回流期间显示出相似的蛋白质反应，但在改道后，它们仅刺激水和碳酸氢盐分泌。3. 在第二个平台期，油酸刺激导致水和碳酸氢盐分泌显著增加，但蛋白质分泌量未显著增加。先前在我们实验室中描述的蛋白质分泌的延迟抑制未改变。4. 超最大剂量的外源性刺激导致胰腺分泌受到抑制。
