针对普鲁卡因胺的天然抗体。
Natural antibodies to procaine amide.
作者信息
Russell A S, Ziff M
出版信息
Clin Exp Immunol. 1968 Nov;3(9):901-9.
A method has been developed for assay of antibody reactive with procaine amide (PrA) which utilizes sheep red blood cells coupled with diazotized PrA. Antibody of the IgM class was found in 19–50% of the populations tested. These included patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, juvenile rheumatoid arthritis, miscellaneous diseases, cardiac patients receiving PrA and normal adults. Only 6% of patients with PrA-induced systemic lupus erythematosus had antibody. Antibody was not found in neonatal children, nor in rabbits and hamsters, but was found in 78% of normal dogs. Immunization of rabbits with a PrA–bovine serum albumin complex induced anti-PrA antibody in high titre. Antibody titres in these rabbits and in man could be abolished by addition of PrA to the titration system. Seventy-four per cent of unselected patients receiving PrA for over 2 months were found to have antinuclear antibody in significant titre. It is suggested that the high incidence of antinuclear antibody and SLE-like disease in patients receiving PrA may be related to the wide occurrence of natural antibody to PrA.
已开发出一种检测与普鲁卡因酰胺（PrA）反应的抗体的方法，该方法利用与重氮化PrA偶联的绵羊红细胞。在19%至50%的受测人群中发现了IgM类抗体。这些人群包括系统性红斑狼疮（SLE）患者、类风湿性关节炎患者、青少年类风湿性关节炎患者、其他杂病患者、接受PrA治疗的心脏病患者以及正常成年人。仅6%的PrA诱发的系统性红斑狼疮患者有抗体。新生儿、兔子和仓鼠中未发现抗体，但78%的正常犬中有抗体。用PrA - 牛血清白蛋白复合物免疫兔子可诱导产生高滴度的抗PrA抗体。在这些兔子和人类中，通过在滴定系统中加入PrA可消除抗体滴度。发现74%接受PrA治疗超过2个月的未经挑选的患者有显著滴度的抗核抗体。有人提出，接受PrA治疗的患者中抗核抗体和SLE样疾病的高发病率可能与对PrA天然抗体的广泛存在有关。
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