[脾切除术对造血系统疾病患者血清血小板生成活性（ATS）的影响]

[Effect of splenectomy on blood serum thrombopoietic activity (ATS) in patients with hematopoietic diseases].

作者信息

Sylwestrowicz T, Sokołowska K, Szczepanik A, Pawelski S

出版信息

Acta Haematol Pol. 1981 Jan-Mar;12(1):29-36.

Abstract

Thrombocytopoietic activity (ATS) was determined in tests on mice on the day before and on the 1st, 7th, and 14th days after splenectomy in 18 patients (13 with idiopathic thrombocytopenia, 5 with haemolytic anaemia). It was found that in patients with ITP and high-grade splenic destruction of platelets ATS increased on the first days after splenectomy. On the other hand, in ITP patients with low-grade splenic platelet destruction splenectomy decreased the value of ATS immediately after the operation. Splenectomy performed in cases with normal platelet count caused no greater changes in ATS in the first week. These observations suggest that in patients with increased splenic destruction of platelets ATS may be inhibited and this inhibition may be removed after splenectomy. Absent correlation between ATS and platelet count may indicate that the value of ATS is not of decisive importance in thrombocytopenia regression following splenectomy.

摘要

对18例患者（13例特发性血小板减少症患者，5例溶血性贫血患者）在脾切除术前一天以及术后第1天、第7天和第14天进行小鼠试验，以测定血小板生成活性（ATS）。结果发现，在特发性血小板减少性紫癜（ITP）患者以及血小板在脾脏中大量破坏的患者中，脾切除术后第一天ATS升高。另一方面，在血小板在脾脏中轻度破坏的ITP患者中，脾切除术后ATS值立即下降。在血小板计数正常的情况下进行脾切除术，第一周内ATS没有更大变化。这些观察结果表明，在血小板在脾脏中破坏增加的患者中，ATS可能受到抑制，而这种抑制在脾切除术后可能会消除。ATS与血小板计数之间缺乏相关性可能表明，ATS值在脾切除术后血小板减少症消退中并非起决定性作用。