Rogers M P, Trentham D E, McCune W J, Ginsberg B I, Reich P, David J R
Trans Assoc Am Physicians. 1979;92:218-28.
This study shows that psychological stress, produced either by exposure to a predator or by movement and handling, can profoundly suppress the clinical and histologic manifestations of collagen-induced arthritis. In addition, stress can dissociate the development of humoral and cellular sensitivity to collagen from the occurrence of arthritis. Thus stress modalities provide a means of acquiring additional insights into the pathogenesis of collagen-induced arthritis in rats. Such studies may lead to a further understanding of the relationship between emotional states and the functioning of the immunologic system. This study further illustrates the need to identify and control for the effects of stress in animal studies of immunopathology. Finally, the therapeutic implications of this study for autoimmune diseases would appear self-evident (Fig. 7).
本研究表明，暴露于捕食者或移动及处理所产生的心理应激，可显著抑制胶原诱导性关节炎的临床和组织学表现。此外，应激可使对胶原的体液和细胞敏感性的发展与关节炎的发生相分离。因此，应激方式为深入了解大鼠胶原诱导性关节炎的发病机制提供了一种手段。此类研究可能会进一步加深对情绪状态与免疫系统功能之间关系的理解。本研究进一步说明了在免疫病理学动物研究中识别和控制应激影响的必要性。最后，本研究对自身免疫性疾病的治疗意义似乎是不言而喻的（图7）。
