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1
Specificity of anti-type II collagen antibody response in rats.大鼠抗II型胶原抗体反应的特异性
Clin Exp Immunol. 1984 Jul;57(1):57-62.
2
The anti-arthritic and immunosuppressive effects of cyclosporine on arthritis induced in the rat by type II collagen.环孢素对II型胶原诱导的大鼠关节炎的抗关节炎和免疫抑制作用。
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Collagen-induced arthritis in rats. Examination of the epitope specificities of circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type II collagens.大鼠胶原诱导性关节炎。使用从异源和同源II型胶原中纯化的溴化氰衍生肽，检测远交系和近交系大鼠产生的循环抗体和软骨结合抗体的表位特异性。
J Immunol. 1992 Aug 1;149(3):1045-53.
4
Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II.用异源和同源II型胶原蛋白免疫DBA/1小鼠后关节炎的发病率及抗胶原蛋白抗体的自身反应性
Clin Exp Immunol. 1985 Dec;62(3):639-46.
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Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis.II型胶原自身免疫的免疫遗传学与胶原性关节炎易感性
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Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule.小鼠Ⅱ型胶原诱导性关节炎。IV. 免疫遗传调控的变化为胶原分子上多个致关节炎表位提供了证据。
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引用本文的文献

1
Cell-mediated transfer of collagen-induced arthritis in mice and its application to the analysis of the inhibitory effects of interferon-gamma and cyclophosphamide.小鼠中胶原诱导性关节炎的细胞介导转移及其在分析γ-干扰素和环磷酰胺抑制作用中的应用
Clin Exp Immunol. 1993 May;92(2):328-35. doi: 10.1111/j.1365-2249.1993.tb03400.x.
2
Epitope specificity of antibody response against human type II collagen in the mouse susceptible to collagen-induced arthritis and patients with rheumatoid arthritis.在易患胶原诱导性关节炎的小鼠和类风湿性关节炎患者中，针对人II型胶原的抗体反应的表位特异性。
Clin Exp Immunol. 1988 Sep;73(3):443-8.
3
The effect of treatment with interferon-gamma on type II collagen-induced arthritis.γ-干扰素治疗对Ⅱ型胶原诱导性关节炎的影响。
Clin Exp Immunol. 1990 Sep;81(3):441-5. doi: 10.1111/j.1365-2249.1990.tb05353.x.

本文引用的文献

1
Autoimmunity to collagen in adjuvant arthritis of rats.大鼠佐剂性关节炎中对胶原蛋白的自身免疫反应。
J Clin Invest. 1980 Nov;66(5):1109-17. doi: 10.1172/JCI109940.
2
Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide.使用合成的胞壁酰二肽有效诱导胶原性关节炎。
Arthritis Rheum. 1980 Sep;23(9):993-7. doi: 10.1002/art.1780230905.
3
Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.大鼠天然II型胶原诱导性关节炎。I. 对胶原的发病率及体液反应
Ann Rheum Dis. 1980 Jun;39(3):285-90. doi: 10.1136/ard.39.3.285.
4
Collagen-induced arthritis in the rat: modification of immune and arthritic responses by free collagen and immune anti-collagen antiserum.大鼠胶原诱导性关节炎：游离胶原和免疫抗胶原抗血清对免疫和关节炎反应的影响
Immunology. 1981 Dec;44(4):737-44.
5
Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis.大鼠Ⅱ型胶原诱导性关节炎。血清被动转移及IgG抗胶原抗体可引发关节炎的证据。
J Exp Med. 1982 Jan 1;155(1):1-16. doi: 10.1084/jem.155.1.1.
6
Serum transfer of collagen-induced arthritis in mice.小鼠胶原诱导性关节炎的血清转移
J Exp Med. 1983 Aug 1;158(2):378-92. doi: 10.1084/jem.158.2.378.
7
Adjuvant arthritis: immunopathological and hyperalgesic features.佐剂性关节炎：免疫病理学和痛觉过敏特征
Fed Proc. 1982 Jul;41(9):2577-82.
8
Immune recognition of serum albumin--XIII. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin.血清白蛋白的免疫识别——十三。兔抗牛或人血清白蛋白抗体对兔血清白蛋白的自身反应性及兔血清白蛋白的自身免疫识别
Mol Immunol. 1981 Nov;18(11):961-7. doi: 10.1016/0161-5890(81)90113-9.
9
The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species.对肌红蛋白的抗体反应与免疫物种无关。分析了在不同物种中产生的十五种肌红蛋白与抹香鲸肌红蛋白抗血清交叉反应的抗原位点和环境残基中的替换情况。
Biochem J. 1980 Dec 1;191(3):681-97. doi: 10.1042/bj1910681.
10
Microtiter solid-phase radioimmunoassay for specific immunoglobulin E.
J Allergy Clin Immunol. 1981 Apr;67(4):263-71. doi: 10.1016/0091-6749(81)90020-8.

大鼠抗II型胶原抗体反应的特异性

Specificity of anti-type II collagen antibody response in rats.

作者信息

Kakimoto K, Hirofuji T, Koga T

出版信息

Clin Exp Immunol. 1984 Jul;57(1):57-62.

PMID:6744675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536100/
Abstract

Specificity of the rat antibody against type II collagen was investigated using rat, bovine and human type II collagen preparations. PVG/c rats showed the highest antibody level in assays with autologous rat type II collagen than with heterologous (bovine or human) type II collagen even when immunized with heterologous one. On the other hand, the rat exhibited significantly low antibody response when they were immunized with autologous type II collagen. The results indicate that rats develop strong antibody response against self type II collagen when immunized with heterologous collagen and this unique specificity of anti-type II collagen antibody response suggests that autoimmunity is involved in the pathogenesis of collagen-induced arthritis in rats.

摘要

使用大鼠、牛和人II型胶原制剂研究了大鼠抗II型胶原抗体的特异性。即使使用异源（牛或人）II型胶原免疫，PVG/c大鼠在用自体大鼠II型胶原进行的检测中显示出的抗体水平也高于用异源II型胶原进行检测时的抗体水平。另一方面，当用自体II型胶原免疫时，大鼠表现出明显较低的抗体反应。结果表明，大鼠在用异源胶原免疫时会针对自身II型胶原产生强烈的抗体反应，这种抗II型胶原抗体反应的独特特异性表明自身免疫参与了大鼠胶原诱导性关节炎的发病机制。