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大鼠抗II型胶原抗体反应的特异性

Specificity of anti-type II collagen antibody response in rats.

作者信息

Kakimoto K, Hirofuji T, Koga T

出版信息

Clin Exp Immunol. 1984 Jul;57(1):57-62.

PMID:6744675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536100/
Abstract

Specificity of the rat antibody against type II collagen was investigated using rat, bovine and human type II collagen preparations. PVG/c rats showed the highest antibody level in assays with autologous rat type II collagen than with heterologous (bovine or human) type II collagen even when immunized with heterologous one. On the other hand, the rat exhibited significantly low antibody response when they were immunized with autologous type II collagen. The results indicate that rats develop strong antibody response against self type II collagen when immunized with heterologous collagen and this unique specificity of anti-type II collagen antibody response suggests that autoimmunity is involved in the pathogenesis of collagen-induced arthritis in rats.

摘要

使用大鼠、牛和人II型胶原制剂研究了大鼠抗II型胶原抗体的特异性。即使使用异源（牛或人）II型胶原免疫，PVG/c大鼠在用自体大鼠II型胶原进行的检测中显示出的抗体水平也高于用异源II型胶原进行检测时的抗体水平。另一方面，当用自体II型胶原免疫时，大鼠表现出明显较低的抗体反应。结果表明，大鼠在用异源胶原免疫时会针对自身II型胶原产生强烈的抗体反应，这种抗II型胶原抗体反应的独特特异性表明自身免疫参与了大鼠胶原诱导性关节炎的发病机制。

相似文献

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Epitope specificity of antibody response against human type II collagen in the mouse susceptible to collagen-induced arthritis and patients with rheumatoid arthritis.在易患胶原诱导性关节炎的小鼠和类风湿性关节炎患者中，针对人II型胶原的抗体反应的表位特异性。
Clin Exp Immunol. 1988 Sep;73(3):443-8.
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The effect of treatment with interferon-gamma on type II collagen-induced arthritis.γ-干扰素治疗对Ⅱ型胶原诱导性关节炎的影响。
Clin Exp Immunol. 1990 Sep;81(3):441-5. doi: 10.1111/j.1365-2249.1990.tb05353.x.

本文引用的文献

1
Autoimmunity to collagen in adjuvant arthritis of rats.大鼠佐剂性关节炎中对胶原蛋白的自身免疫反应。
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Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide.使用合成的胞壁酰二肽有效诱导胶原性关节炎。
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Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.大鼠天然II型胶原诱导性关节炎。I. 对胶原的发病率及体液反应
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Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis.大鼠Ⅱ型胶原诱导性关节炎。血清被动转移及IgG抗胶原抗体可引发关节炎的证据。
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Serum transfer of collagen-induced arthritis in mice.小鼠胶原诱导性关节炎的血清转移
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Adjuvant arthritis: immunopathological and hyperalgesic features.佐剂性关节炎：免疫病理学和痛觉过敏特征
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Immune recognition of serum albumin--XIII. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin.血清白蛋白的免疫识别——十三。兔抗牛或人血清白蛋白抗体对兔血清白蛋白的自身反应性及兔血清白蛋白的自身免疫识别
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The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species.对肌红蛋白的抗体反应与免疫物种无关。分析了在不同物种中产生的十五种肌红蛋白与抹香鲸肌红蛋白抗血清交叉反应的抗原位点和环境残基中的替换情况。
Biochem J. 1980 Dec 1;191(3):681-97. doi: 10.1042/bj1910681.
10
Microtiter solid-phase radioimmunoassay for specific immunoglobulin E.
J Allergy Clin Immunol. 1981 Apr;67(4):263-71. doi: 10.1016/0091-6749(81)90020-8.

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